Blood biomarkers and functional disability among extremely longevous individuals: a population-based study.
Blood biomarkers and functional disability among extremely longevous individuals: a population-based study.
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DOI：
10.1093/gerona/glu229
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发表时间：
2015-05
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影响因子：
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通讯作者：
Zuyun Liu;Yong Wang;Jiapin Huang;X. Chu;D. Qian;Zhengdong Wang;Xunming Sun;Fei Chen;Jun Xu;Shilin Li;L. Jin;Xiaofeng Wang
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文献类型：
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作者：
Zuyun Liu;Yong Wang;Jiapin Huang;X. Chu;D. Qian;Zhengdong Wang;Xunming Sun;Fei Chen;Jun Xu;Shilin Li;L. Jin;Xiaofeng Wang
背景技术一些血液生物标志物与功能障碍（普通人群的健康问题）有关。然而，用于评估生物标志物与极长寿（95 岁以上）人群功能障碍之间潜在关联的数据有限。方法 我们使用了如皋长寿队列中 420 名极其长寿个体的数据，这是一项在中国长寿之乡如皋进行的基于人群的关联研究。功能障碍通过日常生活活动卡茨独立指数进行评估。血液生物标志物，包括血清脂质、脂蛋白胆固醇、血清白蛋白和淋巴细胞计数，与日常生活活动相关。结果 在极其长寿的女性中，随着功能障碍的程度，血清白蛋白和淋巴细胞计数显着下降（所有趋势 p < .001）。在单变量模型中，血清白蛋白（β = -0.279，p < .001）、淋巴细胞计数（β = -0.187，p < .001）和中性粒细胞计数（β = 0.140，p = .012）被发现与女性的日常生活活动显着相关。调整其他协变量后，显着性仍然存在。值得注意的是，多变量回归分析揭示了所有三种生物标志物对日常生活活动的独立影响（β = -0.242、-0.185 和 0.143，所有 p < .05）。我们没有观察到男性有任何关联。结论 我们发现，即使在对极长寿女性的潜在混杂因素进行调整后，血清白蛋白、淋巴细胞计数和中性粒细胞计数与身体残疾之间仍存在显着相关性，这需要进一步研究。这些发现为未来的研究提供了初步但重要的线索，特别是在进行干预之前探索兴趣的纵向关系。
BACKGROUND Several blood biomarkers have been linked to functional disability, a health problem in general populations. However, there are limited data for evaluating the potential association of biomarkers with functional disability in an extremely longevous (95+) population. METHODS We used data from 420 extremely longevous individuals from the Rugao longevity cohort, a population-based association study conducted in Rugao, a longevity town in China. Functional disability was assessed by the Katz Index of Independence in activities of daily living. Blood biomarkers, including serum lipid, lipoprotein cholesterol, serum albumin, and lymphocyte count, were correlated with activities of daily living. RESULTS Among extremely longevous women, following the degree of functional disability, serum albumin and lymphocyte count decreased significantly (all p for trend < .001). In a univariate model, serum albumin (β = -0.279, p < .001), lymphocyte count (β = -0.187, p < .001), and neutrophil count (β = 0.140, p = .012) were found to be significantly associated with activities of daily living in women. After adjustment for other covariates, the significance remained. Notably, multivariate regression analysis revealed independent effects of all the three biomarkers on activities of daily living (β = -0.242, -0.185, and 0.143, all p < .05). We did not observe any association in men. CONCLUSIONS We found significant associations between serum albumin, lymphocyte count, and neutrophil count and physical disability even after adjustment for potential confounders in extremely longevous women, which call for further study. The findings provide preliminary but crucial clues for future studies specifically aimed at exploring the longitudinal relationships of interest before proceeding with interventions.