Decreased expression of NDRG2 is related to poor overall survival in patients with glioma
Decreased expression of NDRG2 is related to poor overall survival in patients with glioma
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DOI：
10.1016/j.jocn.2010.12.032
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发表时间：
2011-11-01
影响因子：
2
通讯作者：
Sun, Boqian
中科院分区：
文献类型：
--
作者：
Li, Wei;Chu, Dake;Sun, Boqian
NDRG（N-Myc downstream-regulated）基因家族的成员已被证明在人类恶性肿瘤中发挥多种作用。在本研究中，我们研究了NDRG 2蛋白在WHO分级I-IV的胶质瘤样本中的表达。我们还研究了NDRG 2表达与生存率之间的关系。应用免疫组化方法检测316例人脑胶质瘤组织和41例正常脑组织中NDRG 2蛋白的表达。采用Kaplan-Meier法和考克斯比例风险模型进行生存分析。我们发现，相对于正常组织，神经胶质瘤中NDRG 2的表达减少，并且NDRG 2的表达随着神经胶质瘤级别的升高而减少。Kaplan-Meier分析显示NDRG 2不表达的患者生存率低于其他患者。多因素分析显示NDRG 2表达是影响脑胶质瘤患者总生存率的独立预后因素。本研究首次提供了神经胶质瘤中NDRG 2表达降低的证据，表明NDRG 2可能在神经胶质瘤的发展过程中发挥抑制作用。NDRG 2表达也可能是胶质瘤的一个重要和独立的预后指标。(C)2011爱思唯尔有限公司保留所有权利。
Members of the NDRG (N-Myc downstream-regulated) gene family have been shown to play a variety of roles in human malignancies. In the present study, we examined the expression of NDRG2 protein in glioma samples of WHO grades I-IV. We also investigated the association between NDRG2 expression and survival. Immunohistochemical analysis was used to measure NDRG2 protein expression in 316 specimens of human glioma and 41 normal control tissues. Survival analysis was performed using the Kaplan-Meier method and Cox's proportional hazards model. We found that NDRG2 expression was reduced in glioma relative to normal tissue, and that NDRG2 expression decreased with increasing glioma grade. Kaplan-Meier analysis showed that patients without NDRG2 expression had a lower survival rate than other patients. Multivariate analysis showed that NDRG2 expression was an independent prognostic factor for overall survival of patients with glioma. The present study provides the first evidence that NDRG2 expression is decreased in gliomas, indicating that NDRG2 may play an inhibitory role during the development of gliomas. NDRG2 expression may also be a significant and independent prognostic indicator for glioma. (C) 2011 Elsevier Ltd. All rights reserved.