Development of a standard treatment protocol for severe acute respiratory syndrome.
Development of a standard treatment protocol for severe acute respiratory syndrome.
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DOI：
10.1016/s0140-6736(03)13265-5
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发表时间：
2003-05-10
期刊：
影响因子：
--
通讯作者：
Yuen KY
中科院分区：
文献类型：
--
作者：
So LK;Lau AC;Yam LY;Cheung TM;Poon E;Yung RW;Yuen KY
一系列的31例疑似SARS患者，诊断从WHO标准，治疗方案包括抗菌药物和利巴韦林和甲基强的松龙的组合。通过前11例患者的经验，我们能够最终确定标准剂量方案，包括脉冲甲基强的松龙。1例患者仅接受抗菌治疗后痊愈，17例患者表现出快速和持续的反应，13例患者在逐步增加或脉冲甲基强的松龙治疗后获得改善。4例患者需要短期无创通气。没有患者需要插管或机械通气。在该系列中没有死亡或治疗发病率。
A series of 31 patients with probable SARS, diagnosed from WHO criteria, were treated according to a treatment protocol consisting of antibacterials and a combination of ribavirin and methylprednisolone. Through experience with the first 11 patients, we were able to finalise standard dose regimens, including pulsed methylprednisolone. One patient recovered on antibacterial treatment alone, 17 showed rapid and sustained responses, and 13 achieved improvement with step-up or pulsed methylprednisolone. Four patients required short periods of non-invasive ventilation. No patient required intubation or mechanical ventilation. There was no mortality or treatment morbidity in this series.