Directionally selective calcium signals in dendrites of starburst amacrine cells
Directionally selective calcium signals in dendrites of starburst amacrine cells
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DOI：
10.1038/nature00931
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发表时间：
2002-08-22
期刊：
影响因子：
64.8
通讯作者：
Denk, W
中科院分区：
文献类型：
--
作者：
Euler, T;Detwiler, PB;Denk, W
图像运动的检测是视觉的基础。在许多物种中，视网膜神经节细胞的独特类别选择性地响应在特定方向上移动的视觉刺激。目前还不知道哪一个视网膜细胞首先执行神经计算，从而在神经节细胞中产生方向选择性。一个突出的候选者是被称为“星爆无长突细胞”的中间神经元。使用双光子光学记录细胞内钙离子浓度，在这里，我们发现，个别树突状分支的星爆细胞作为独立的计算模块。树突钙信号，而不是体细胞膜电压，是定向选择性的刺激，从细胞索马离心。这表明，在神经节细胞之前的阶段，在树突状分支中局部计算方向选择性。
The detection of image motion is fundamental to vision. In many species, unique classes of retinal ganglion cells selectively respond to visual stimuli that move in specific directions. It is not known which retinal cell first performs the neural computations that give rise to directional selectivity in the ganglion cell. A prominent candidate has been an interneuron called the 'starburst amacrine cell'. Using two-photon optical recordings of intracellular calcium concentration, here we find that individual dendritic branches of starburst cells act as independent computation modules. Dendritic calcium signals, but not somatic membrane voltage, are directionally selective for stimuli that move centrifugally from the cell soma. This demonstrates that direction selectivity is computed locally in dendritic branches at a stage before ganglion cells.