The complex interplay between mitochondrial dynamics and cardiac metabolism.

The complex interplay between mitochondrial dynamics and cardiac metabolism.
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DOI:
10.1007/s10863-011-9332-0
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发表时间:
2011-02
影响因子:
3
通讯作者:
Lavandero, Sergio
Lavandero, Sergio
中科院分区:
生物学4区
文献类型:
--
作者:
Parra, Valentina;Verdejo, Hugo;del Campo, Andrea;Pennanen, Christian;Kuzmicic, Jovan;Iglewski, Myriam;Hill, Joseph A.;Rothermel, Beverly A.;Lavandero, Sergio

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线粒体是高度动态的细胞器,能够经历不断的裂变和融合事件,形成网络。这些动态事件允许化学和物理信使的传输以及细胞内代谢物的交换。本文综述了控制线粒体分裂和融合的信号机制及其与细胞生物能量学的关系,特别是在心脏中。此外,我们还讨论了线粒体动力学缺陷可能参与代谢性心脏病的发病机制。
Mitochondria are highly dynamic organelles, capable of undergoing constant fission and fusion events, forming networks. These dynamic events allow the transmission of chemical and physical messengers and the exchange of metabolites within the cell. In this article we review the signaling mechanisms controlling mitochondrial fission and fusion, and its relationship with cell bioenergetics, especially in the heart. Furthermore we also discuss how defects in mitochondrial dynamics might be involved in the pathogenesis of metabolic cardiac diseases.
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