RABIES VIRUS SELECTIVELY ALTERS 5-HT(1) RECEPTOR SUBTYPES IN RAT-BRAIN
RABIES VIRUS SELECTIVELY ALTERS 5-HT(1) RECEPTOR SUBTYPES IN RAT-BRAIN
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DOI：
10.1016/0922-4106(93)90120-x
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发表时间：
1993-04-15
期刊：
影响因子：
--
通讯作者：
FILLION, G
中科院分区：
文献类型：
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作者：
CECCALDI, PE;FILLION, MP;FILLION, G
人类狂犬病病毒感染可引起一系列临床症状，其中一些提示涉及中枢神经系统。本研究的结果表明，狂犬病毒感染大鼠5天后，海马中[H-3]5-HT的总可逆高亲和力结合不受影响，表明5-HT 1A结合没有改变。通过[I-125]氰基吲哚酚结合鉴定的5-HT 1B位点在感染后3天和5天在皮质中不受影响。因此，三氟甲基苯基哌嗪（TFMPP）对[H-3]乙酰胆碱诱发的释放的细胞抑制作用，可能与5-HT 1B受体活性有关，感染后3天没有改变。相反，在存在掩蔽5-HT 1A、5-HT 1B和5-HT 1C受体的药物的情况下测定的[H-3]5-HT结合在病毒感染后3天显著（50%）降低。这些结果表明，5-HT 1D样受体亚型可能会受到影响，具体和在狂犬病病毒感染后的早期阶段。
Rabies virus infection in man induces a series of clinical symptoms, some suggesting involvement of the central serotonergic system. The results of the present study show that, 5 days after rabies virus infection in rat, the total reversible high-affinity binding of [H-3]5-HT in the hippocampus is not affected, suggesting that 5-HT1A binding is not altered. 5-HT1B sites identified by [I-125]cyanopindolol binding are not affected in the cortex 3 and 5 days after the infection. Accordingly, the cellular inhibitory effect of trifluoromethylphenylpiperazine (TFMPP) on the [H-3]acetylcholine-evoked release, presumably related to 5-HT1B receptor activity, is not modified 3 days after infection. In contrast, [H-3]5-HT binding determined in the presence of drugs masking 5-HT1A, 5-HT1B and 5-HT1C receptors, is markedly (50%) reduced 3 days after the viral infection. These results suggest that 5-HT1D-like receptor subtypes may be affected specifically and at an early stage after rabies viral infection.