Smart self-assembled hybrid hydrogel biomaterials.
Smart self-assembled hybrid hydrogel biomaterials.
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DOI：
10.1002/anie.201201040
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发表时间：
2012-07-23
期刊：
影响因子：
--
通讯作者：
Yang J
中科院分区：
文献类型：
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作者：
Kopeček J;Yang J
混合生物材料是由至少两种不同类别的分子的组分产生的系统，例如，合成大分子和蛋白质或肽结构域。两种类型的结构的协同组合可以产生具有前所未有的结构组织水平和新颖性能的新材料。本文综述了生物降解驱动的杂化大分子自组装成功能性水凝胶生物材料。首先，管理的二级结构的肽的基本规则进行了讨论，然后评估的具体设计的混合动力系统与定制的性能的方法，然后由生物材料和大分子治疗的设计原理的相似性的讨论。最后，简要介绍了该领域的未来
Hybrid biomaterials are systems created from components of at least two distinct classes of molecules, for example, synthetic macromolecules and proteins or peptide domains. The synergistic combination of two types of structures may produce new materials that possess unprecedented levels of structural organization and novel properties. This Review focuses on biorecognition-driven self-assembly of hybrid macromolecules into functional hydrogel biomaterials. First, basic rules that govern the secondary structure of peptides are discussed, and then approaches to the specific design of hybrid systems with tailor-made properties are evaluated, followed by a discussion on the similarity of design principles of biomaterials and macromolecular therapeutics. Finally, the future of the field is briefly