MEDULLASIN ACTIVITY IN GRANULOCYTES OF PATIENTS WITH MULTIPLE-SCLEROSIS
MEDULLASIN ACTIVITY IN GRANULOCYTES OF PATIENTS WITH MULTIPLE-SCLEROSIS
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DOI：
10.1002/ana.410150307
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发表时间：
1984-01-01
影响因子：
11.2
通讯作者：
YOSHIDA, M
中科院分区：
文献类型：
--
作者：
AOKI, Y;MIYATAKE, T;YOSHIDA, M
在 22 名多发性硬化症 [MS] 患者的血液中测量了成熟粒细胞中的髓质素活性（确定型，16 例；可能型，6 例）。每个复发患者的活性均升高；在改善开始时下降到接近正常水平，并在缓解时进一步下降到正常水平。对 3 名患者髓质素活性水平的连续测定显示，在急性加重发生前几天，髓质素活性增加。除 2 名脊髓小脑变性患者外，从除 MS 以外的神经系统疾病患者中获得的成熟粒细胞中髓质素活性水平大部分在正常范围内。成熟粒细胞中髓质素活性的测量可能有助于多发性硬化症的诊断和评估。
Medullasin activity in mature granulocytes was measured in the blood of 22 patients with multiple sclerosis [MS] (definite type, 16; probable type, 6). The activity was elevated in every patient in relapse; it decreased to nearly normal levels at the beginning of improvement and further decreased to normal levels with remission. Serial determination of the level of medullasin activity in 3 patients revealed that activity increased several days before the onset of acute exacerbation. Medullasin activity level in mature granulocytes obtained from patients with neurological diseases other than MS was largely within the normal range, except in 2 patients with spinocerebellar degeneration. Measurement of medullasin activity in mature granulocytes may become useful in both diagnosis and evaluation of MS.