Biomechanical Evaluation of Amorphous Calcium Phosphate Coated TNTZ Implants Prepared Using a Radiofrequency Magnetron Sputtering System
Biomechanical Evaluation of Amorphous Calcium Phosphate Coated TNTZ Implants Prepared Using a Radiofrequency Magnetron Sputtering System
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DOI：
10.2320/matertrans.m2012075
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发表时间：
2012-07-01
影响因子：
1.2
通讯作者：
Suzuki, Osamu
中科院分区：
文献类型：
--
作者：
Shiraishi, Naru;Tu, Rong;Suzuki, Osamu
Ti-29 Nb-13 Ta-4.6Zr合金（TNTZ）是一种新型的β型钛合金，具有弹性模量低、无过敏原、无细胞毒性等优点。然而，目前尚不清楚TNTZ是否能够实现足够的骨结合以用作牙科植入物。通过射频（RF）磁控溅射对TNTZ植入物进行表面改性的有效性也不清楚。我们研究了TNTZ种植体在体内的生物力学行为，使用四种类型的圆柱形种植体：纯钛，TNTZ，纯钛和TNTZ涂层无定形磷酸钙（ACP）。将植入物插入大鼠股骨中，并在不同时间间隔后对股骨进行生物力学分析。结果表明，TNTZ种植体可以实现类似于纯钛的骨整合，并且通过RF磁控溅射用ACP进行表面改性可以改善骨整合，特别是在愈合的后期阶段。doi：10.2320/matertrans.M2012078]
Ti-29Nb-13Ta-4.6Zr alloy (TNTZ), a new beta-type Ti alloy, has excellent advantages as a biomaterial, such as low Young's modulus and cytotoxicity, and the absence of allergens. However, it is unclear whether TNTZ can achieve sufficient osseointcgration for it to be used as a dental implant. The effectiveness of surface modification of TNTZ implants by radiofrequency (RF) magnetron sputtering is also unclear. We investigated the biomechanical behaviors of TNTZ implants in vivo, using cylindrical implants of four types: pure Ti, TNTZ, and pure Ti and TNTZ coated with amorphous calcium phosphate (ACP). The implants were inserted in rat femurs, and the femurs were subjected to biomechanical analyses after various time intervals. The results suggest that TNTZ implants can achieve osseointegration similar to that of pure Ti, and that surface modification with ACP by RF magnetron sputtering improves osseointegration, especially in the later stages of healing. doi:10.2320/matertrans.M2012078]