A 3D numerical study of the collateral capacity of the Circle of Willis with anatomical variation in the posterior circulation.
A 3D numerical study of the collateral capacity of the Circle of Willis with anatomical variation in the posterior circulation.
复制标题
后循环解剖变异下 Willis 环侧支容量的 3D 数值研究
DOI：
10.1186/1475-925x-14-s1-s11
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发表时间：
2015
影响因子：
3.9
通讯作者：
Li ZY
中科院分区：
文献类型：
--
作者：
Ren Y;Chen Q;Li ZY
背景Willis环（Circle of Willis，CoW）是脑动脉最重要的侧支循环。本研究旨在探讨单侧颈内动脉（伊卡）闭塞时，冠状动脉后循环的侧支循环容量与解剖变异的关系。方法基于MRI数据，我们重建了8个冠状动脉后循环变异的三维模型，并在右侧伊卡设置4个不同程度的狭窄，分别为24%、43%、64%和79%。最后，共40个模型进行了计算流体动力学模拟。所有的模拟具有相同的边界条件与静态压力和体积流量（VFR），以评估其侧支capacity.ResultsFor大脑中动脉（MCA）和大脑前动脉（ACA），过渡型模型具有最好的侧支容量。而对于大脑后动脉（PCA），单侧伊卡狭窄对单侧后交通动脉（PCoA）缺如模型的影响最小。我们还发现，胎儿型Willis后环是一个极其危险的变异，必须引起更多的关注。结论不同的模型在应对单侧伊卡狭窄时具有不同的侧支循环能力，这种差异可以通过不同的出口反映出来。本研究可作为神经外科医生选择最佳治疗策略的参考。
BackgroundThe Circle of Willis (CoW) is the most important collateral pathway of the cerebral artery. The present study aims to investigate the collateral capacity of CoW with anatomical variation when unilateral internalcarotid artery (ICA) is occluded.MethodsBasing on MRI data, we have reconstructed eight 3D models with variations in the posterior circulation of the CoW and set four different degrees of stenosis in the right ICA, namely 24%, 43%, 64% and 79%, respectively. Finally, a total of 40 models are performed with computational fluid dynamics simulations. All of the simulations share the same boundary condition with static pressure and the volume flow rate (VFR) are obtained to evaluate their collateral capacity.ResultsAs for the middle cerebral artery (MCA) and the anterior cerebral artery (ACA), the transitional-type model possesses the best collateral capacity. But for the posterior cerebral artery (PCA), unilateral stenosis of ICA has the weakest influence on the unilateral posterior communicating artery (PCoA) absent model. We also find that the full fetal-type posterior circle of Willis is an utmost dangerous variation which must be paid more attention.ConclusionThe results demonstrate that different models have different collateral capacities in coping stenosis of unilateral ICA and these differences can be reflected by different outlets. The study could be used as a reference for neurosurgeon in choosing the best treatment strategy.