Exercise enhances learning and hippocampal neurogenesis in aged mice
Exercise enhances learning and hippocampal neurogenesis in aged mice
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DOI：
10.1523/jneurosci.1731-05.2005
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发表时间：
2005-09-21
影响因子：
5.3
通讯作者：
Gage, FH
中科院分区：
文献类型：
--
作者：
van Praag, H;Shubert, T;Gage, FH
衰老导致海马体的变化，可能导致老年人的认知能力下降。在年轻的动物中，运动增加海马神经发生并改善学习。我们调查了自愿的车轮运行是否会使久坐不动的小鼠受益，直到19个月大。具体地说，年轻和年老的小鼠被安置在有或没有转轮的情况下，并注射溴脱氧尿苷或逆转录病毒来标记新生细胞。1个月后，在Morris水迷宫中测试学习。老年跑步者比年龄匹配的对照组表现出更快的迷宫获取和更好的保持。通过跑步，老年小鼠神经发生的下降被逆转到年轻对照水平的50%。此外，新生神经元的精细形态在年轻和老年跑步者之间没有差异，表明新生神经元的初始成熟不受衰老的影响。因此，自愿运动改善了一些老化的有害形态和行为后果。
Aging causes changes in the hippocampus that may lead to cognitive decline in older adults. In young animals, exercise increases hippocampal neurogenesis and improves learning. We investigated whether voluntary wheel running would benefit mice that were sedentary until 19 months of age. Specifically, young and aged mice were housed with or without a running wheel and injected with bromodeoxyuridine or retrovirus to label newborn cells. After 1 month, learning was tested in the Morris water maze. Aged runners showed faster acquisition and better retention of the maze than age-matched controls. The decline in neurogenesis in aged mice was reversed to 50% of young control levels by running. Moreover, fine morphology of new neurons did not differ between young and aged runners, indicating that the initial maturation of newborn neurons was not affected by aging. Thus, voluntary exercise ameliorates some of the deleterious morphological and behavioral consequences of aging.