A closer look at weight loss interventions in primary care: a systematic review and meta-analysis.
A closer look at weight loss interventions in primary care: a systematic review and meta-analysis.
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DOI：
10.3389/fmed.2023.1204849
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发表时间：
2023
影响因子：
3.9
通讯作者：
Argyropoulos, Christos
中科院分区：
文献类型：
--
作者：
Perreault, Leigh;Kramer, E. Seth;Smith, Peter C.;Schmidt, Darren;Argyropoulos, Christos
主要目的是使用由初级保健提供者管理的各种方法量化患者体重减轻至少6个月，并揭示可以长期改善患者体重减轻的相关背景因素。使用科克伦对照试验中心注册库、MEDLINE、EMBASE、Scopus和Web of Science从研究开始至2022年12月5日进行了系统综述和荟萃分析。使用COVIDENCE系统综述软件识别和提取数据，并评估数据质量和偏倚风险。7项研究包括2，187名接受肥胖测试的人（1）抗肥胖药物（AOM），（2）AOM，强化生活方式咨询+代餐，以及（3）医生培训，以更好地为患者提供强化生活方式改变的建议。观察到结果的显著异质性，以及缺乏显示无影响的已发表研究的偏倚。随机效应模型估计初级保健干预的总体疗效的治疗效应为−3.54 kg（95%CI：−5.61 kg至−1.47 kg）。包括药物成分的干预（单独或作为多管齐下干预的一部分）实现了更大的体重减轻-2.94 kg（p < 0.0001）。在所有干预措施中，疗效均随时间推移而下降（每6个月体重减轻0.53 kg，95% CI：0.04-1.0 kg）。由初级保健提供者管理的减肥干预措施可以导致适度的体重减轻。如果抗肥胖药物是治疗的一部分，体重减轻约一倍。然而，随着时间的推移，体重减轻的减弱强调了长期治疗的必要性。[https://www.crd.york.ac.uk/prospero/ CRD 4202121242344]，标识符（CRD 42021242344）。
The major aims were to quantify patient weight loss using various approaches adminstered by a primary care provider for at least 6 months and to unveil relevant contextual factors that could improve patient weight loss on a long-term basis. A systematic review and meta-analysis was conducted using Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, Scopus, and Web of Science from inception to December 5, 2022. COVIDENCE systematic review software was used to identify and abstract data, as well as assess data quality and risk of bias. Seven studies included 2,187 people with obesity testing (1) anti-obesity medication (AOM), (2) AOM, intensive lifestyle counseling + meal replacements, and (3) physician training to better counsel patients on intensive lifestyle modification. Substantial heterogeneity in the outcomes was observed, as well as bias toward lack of published studies showing no effect. The random effect model estimated a treatment effect for the aggregate efficacy of primary care interventions −3.54 kg (95% CI: −5.61 kg to −1.47 kg). Interventions that included a medication component (alone or as part of a multipronged intervention) achieved a greater weight reduction by −2.94 kg (p < 0.0001). In all interventions, efficacy declined with time (reduction in weight loss by 0.53 kg per 6 months, 95% CI: 0.04–1.0 kg). Weight loss interventions administered by a primary care provider can lead to modest weight loss. Weight loss is approximately doubled if anti-obesity medication is part of the treatment. Nevertheless, attenuated weight loss over time underscores the need for long-term treatment. [https://www.crd.york.ac.uk/prospero/ CRD4202121242344], identifier (CRD42021242344).
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DOI：
10.1056/nejmoa1506699
发表时间：
2016-01-14
期刊：
The New England journal of medicine
影响因子：
--
作者：
Inge TH;Courcoulas AP;Jenkins TM;Michalsky MP;Helmrath MA;Brandt ML;Harmon CM;Zeller MH;Chen MK;Xanthakos SA;Horlick M;Buncher CR;Teen-LABS Consortium
通讯作者：
Teen-LABS Consortium
DOI：
10.1136/bmj.b2535
发表时间：
2009-07-21
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Moher D;Liberati A;Tetzlaff J;Altman DG;PRISMA Group
通讯作者：
PRISMA Group
影响因子：
11.1
作者：
Lindgärde, F
通讯作者：
Lindgärde, F
影响因子：
5.8
作者：
Johannsen, Darcy L.;Knuth, Nicolas D.;Hall, Kevin D.
通讯作者：
Hall, Kevin D.
影响因子：
6.9
作者：
Martin, Pamela Davis;Rhode, Paula C.;Brantley, Phillip J.
通讯作者：
Brantley, Phillip J.