Discovery of fifth serotype of dengue virus (DENV-5): A new public health dilemma in denguecontrol.
Discovery of fifth serotype of dengue virus (DENV-5): A new public health dilemma in denguecontrol.
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DOI：
10.1016/j.mjafi.2014.09.011
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发表时间：
2015-01-01
期刊：
影响因子：
--
通讯作者：
Gupta, V
中科院分区：
文献类型：
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作者：
Mustafa, M S;Rasotgi, V;Gupta, V
登革热是一个重新出现的公共卫生问题，世界五分之二的人口面临感染风险。到目前为止，登革热被认为是由四种不同的血清型引起的。第五个变种 DENV-5 已于 2013 年 10 月分离出来。与遵循人类周期的其他四种血清型不同，该血清型遵循森林循环。新血清型出现的可能原因可能是基因重组、自然选择和遗传瓶颈。没有迹象表明印度存在 DENV-5。最近，前景光明的 Chimerivax 四价疫苗的临床试验遭遇了挫折。未来 DENV-5 和更多此类森林毒株的发现可能会进一步阻碍登革热疫苗计划。综合病媒管理是可持续登革热控制的关键。需要进一步的流行病学和生态学研究来检测其他森林登革热菌株。
Dengue fever is a re-emerging public health problem with two-fifths of the world population being at risk of infection. Till now, dengue fever was believed to be caused by four different serotypes. The fifth variant DENV-5 has been isolated in October 2013. This serotype follows the sylvatic cycle unlike the other four serotypes which follow the human cycle. The likely cause of emergence of the new serotype could be genetic recombination, natural selection and genetic bottlenecks. There is no indication of the presence of DENV-5 in India. Recent clinical trials with the promising Chimerivax tetravalent vaccine suffered a setback. Discovery of DENV-5 and more such sylvatic strains in future may further impede the Dengue Vaccine Initiative. Integrated Vector Management holds the key to sustainable dengue control. Further epidemiological and ecological studies are needed to detect additional sylvatic dengue strains.