Development of bronchiolar epithelium: time course of response to oxygen and recovery.
Development of bronchiolar epithelium: time course of response to oxygen and recovery.
复制标题
细支气管上皮的发育：对氧气的反应和恢复的时间过程。
DOI：
10.1152/ajpregu.1988.254.5.r755
复制
发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Massaro,D
中科院分区：
文献类型：
--
作者：
Massaro,GD;McCoy,L;Massaro,D
高氧（大于95%O2）可逆地抑制大鼠出生后早期细支气管上皮的发育。我们现在表明，核数密度每立方厘米的克拉拉和纤毛细胞的正常增加的钝化变得明显在24小时内暴露于O2（年龄2天），并达到最高的最后一天高氧（年龄7天）。组间差异开始消失后48小时内从O2。在空气呼吸期间，克拉拉细胞有丝分裂在1至2天的年龄之间增加了6倍，并在7天的年龄恢复到第1天的值。在O2呼吸，克拉拉细胞有丝分裂增加3倍之间的年龄1和2天，返回到第1天的值由第4天，但表现出第二个高峰后24小时O2（第8天）不存在于未暴露的幼崽。克拉拉细胞器和糖原的体积的差异的发病是可变的，但差异部分或完全消除后48小时O2暴露。我们的结论是高氧可逆地损害克拉拉细胞的有丝分裂。
Hyperoxia (greater than 95% O2) reversibly suppresses the early postnatal development of rat bronchiolar epithelium. We now show that blunting of the normal increase in nuclear numerical density per centimeter cubed of Clara and ciliated cells becomes apparent within 24 h of exposure to O2 (age 2 days) and reaches a maximum on the last day of hyperoxia (age 7 days). The intergroup differences began to disappear within 48 h after removal from O2. During air breathing, Clara cell mitosis increased sixfold between the ages of 1 and 2 days and returned to day 1 values by age 7 days. During O2 breathing, Clara cell mitosis increased threefold between age 1 and 2 days, returned to day 1 values by day 4, but exhibited a second peak 24 h post-O2 (day 8) not present in unexposed pups. The onset of differences in the volume of Clara cell organelles and glycogen was variable, but the differences were partly or completely eliminated 48 h post-O2 exposure. We conclude hyperoxia reversibly impairs mitosis by Clara cells.