Hindlimb movement modulates the activity of rostral fastigial nucleus neurons that process vestibular input.
Hindlimb movement modulates the activity of rostral fastigial nucleus neurons that process vestibular input.
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DOI：
10.1007/s00221-015-4311-z
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发表时间：
2015-08
影响因子：
2
通讯作者：
Yates BJ
中科院分区：
文献类型：
--
作者：
McCall AA;Miller DJ;Catanzaro MF;Cotter LA;Yates BJ
前庭和本体感觉传入信息在中枢神经系统内的整合是姿势调节的关键组成部分。我们最近证明，脑干和后肢信号会聚到前庭核神经元，这样，后肢运动调节这些细胞的活动。然而，目前还不清楚是否也发生在前庭神经核上游，特别是在头端顶核（rFN）的后肢和前庭信号的类似的收敛。我们测试的假设，rFN神经元有类似的反应，后肢运动的前庭核神经元。记录从53 rFN神经元，对后肢运动的去大脑猫。与通常编码后肢运动方向的前庭核神经元（81%的神经元）相反，很少有对腿部运动做出反应的rFN神经元（21%）编码此类信息。相反，大多数rFN神经元对肢体屈曲和伸展都有反应。一半的rFN神经元的活动调制后肢运动接受会聚前庭输入。这些结果表明，rFN神经元接受来自后肢的体感输入，并且rFN神经元的子集整合了前庭和后肢信号。这样的rFN神经元可能执行参与在直立站立和运动期间维持平衡的计算。虽然前庭核神经元与rFN相互连接，但两个区域中对后肢运动敏感的神经元的反应的不同表明它们在协调运动和其他运动期间的姿势反应中发挥不同的作用，这些运动需要肢体位置的变化。
Integration of vestibular and proprioceptive afferent information within the central nervous system is a critical component of postural regulation. We recently demonstrated that labyrinthine and hindlimb signals converge onto vestibular nucleus neurons, such that hindlimb movement modulates the activity of these cells. However, it is unclear whether similar convergence of hindlimb and vestibular signals also occurs upstream from the vestibular nuclei, particularly in the rostral fastigial nucleus (rFN). We tested the hypothesis that rFN neurons have similar responses to hindlimb movement as vestibular nucleus neurons. Recordings were obtained from 53 rFN neurons that responded to hindlimb movement in decerebrate cats. In contrast to vestibular nucleus neurons, which commonly encoded the direction of hindlimb movement (81% of neurons), few rFN neurons (21%) that responded to leg movement encoded such information. Instead, most rFN neurons responded to both limb flexion and extension. Half of the rFN neurons whose activity was modulated by hindlimb movement received convergent vestibular inputs. These results show that rFN neurons receive somatosensory inputs from the hindlimb, and that a subset of rFN neurons integrates vestibular and hindlimb signals. Such rFN neurons likely perform computations that participate in maintenance of balance during upright stance and movement. Although vestibular nucleus neurons are interconnected with the rFN, the dissimilarity of responses of neurons sensitive to hindlimb movement in the two regions suggest that they play different roles in coordinating postural responses during locomotion and other movements which entail changes in limb position.