MicroRNA in cardiovascular calcification: focus on targets and extracellular vesicle delivery mechanisms.
MicroRNA in cardiovascular calcification: focus on targets and extracellular vesicle delivery mechanisms.
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DOI：
10.1161/circresaha.113.300937
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发表时间：
2013-03-29
影响因子：
20.1
通讯作者：
Aikawa E
中科院分区：
文献类型：
--
作者：
Goettsch C;Hutcheson JD;Aikawa E
心血管钙化是慢性炎症性疾病（例如慢性肾病（CKD）、2型糖尿病（T2D）和动脉粥样硬化）的一个显着特征，与显着的发病率和死亡率相关。相似的途径控制骨重塑和血管钙化的概念已被广泛接受，但钙化的确切机制仍然很大程度上未知。 microRNA (miRNA) 作为心血管系统和骨生物学微调调节剂的核心作用已获得认可，并提高了新治疗靶点的可能性。此外，循环 miRNA 已被提议作为多种心血管疾病的生物标志物，但心血管钙化中 miRNA 生物学的知识非常有限。本综述重点关注 miRNA 在心血管疾病中的作用，重点是成骨过程。在此，我们讨论目前对心血管钙化中 miRNA 的理解。此外，我们还鉴定了一组与心血管钙化相关的疾病（CKD、T2D 和动脉粥样硬化）常见的 miRNA，并且我们假设这些 miRNA 可能提供钙化的分子特征。最后，我们讨论这个新的假设，重点是已知的生物学和病理性成骨过程（例如成骨分化、钙化基质囊泡的释放）。本综述的目的是对 miRNA 和钙化之间已知的联系进行有组织的讨论，为心血管钙化中 miRNA 生物学的未来研究提供新兴概念，这对于开发新的治疗策略至关重要。
Cardiovascular calcification is a prominent feature of chronic inflammatory disorders — such as chronic kidney disease (CKD), type 2 diabetes (T2D), and atherosclerosis — that associate with significant morbidity and mortality. The concept that similar pathways control both bone remodeling and vascular calcification is widely accepted, but the precise mechanisms of calcification remain largely unknown. The central role of microRNAs (miRNA) as fine-tune regulators in the cardiovascular system and bone biology has gained acceptance and has raised the possibility for novel therapeutic targets. Additionally, circulating miRNAs have been proposed as biomarkers for a wide range of cardiovascular diseases, but knowledge of miRNA biology in cardiovascular calcification is very limited. This review focuses on the role of miRNA in cardiovascular disease, with emphasis on osteogenic processes. Herein, we discuss the current understanding of miRNAs in cardiovascular calcification. Furthermore, we identify a set of miRNAs common to diseases associated with cardiovascular calcification (CKD, T2D, and atherosclerosis), and we hypothesize that these miRNAs may provide a molecular signature for calcification. Finally, we discuss this novel hypothesis with emphasis on known biological and pathological osteogenic processes (e.g. osteogenic differentiation, release of calcifying matrix vesicles). The aim of this review is to provide an organized discussion of the known links between miRNA and calcification that provide emerging concepts for future studies on miRNA biology in cardiovascular calcification, which will be critical for developing new therapeutic strategies.