Movement disorders induced by gastrointestinal drugs: two paediatric cases.
Movement disorders induced by gastrointestinal drugs: two paediatric cases.
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胃肠道药物引起的运动障碍：2例儿科病例。
DOI：
10.1055/s-2006-923981
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发表时间：
2006
期刊：
影响因子：
1.4
通讯作者：
J. Rotteveel
中科院分区：
文献类型：
--
作者：
J. Elzinga;Y. Hekster;A. Bijl;J. Rotteveel
一些经常处方的胃肠道药物可能会导致儿童和成人的运动障碍。在我们的儿科神经病学中心，我们看到一个3岁的女孩与异常运动，主要是腿部与内心不安（静坐不能），而使用西沙必利。另一名17岁的男性患者在使用雷尼替丁治疗胃窘迫时出现偏身弹症（一只手臂和肩膀剧烈运动，出现投掷样外观）。在这两名儿童中，运动障碍在停药后消失。这些药物引起的运动障碍的病理生理机制可能与组胺在发育中脑的中枢作用有关。这些病例说明了在诊断异常运动障碍的过程中早期警惕可能的药物引起的事件的重要性。
A number of frequently prescribed gastrointestinal drugs can cause movement disorders in children, as well as in adults. In our centre for paediatric neurology, we saw a 3-year-old girl with abnormal movements mostly of the legs with an inner restlessness (akathisia) while using cisapride. Another patient, a 17-year-old male, developed a hemiballism (a fierce movement of one arm and shoulder with a hurling appearance) while using ranitidine for gastric distress. In both children, the movement disorder disappeared after discontinuing the drug. The pathophysiological mechanisms of these drug-induced movement disorders might be related to the central function of histamine in the developing brain. These cases illustrate the importance of being alert for possible drug-induced events early in the process of diagnosing abnormal movement disorders.