PRECISE TARGETING OF THE PATHOLOGY OF THE SIALOGLYCOPROTEIN, PRP, AND VACUOLAR DEGENERATION IN MOUSE SCRAPIE
PRECISE TARGETING OF THE PATHOLOGY OF THE SIALOGLYCOPROTEIN, PRP, AND VACUOLAR DEGENERATION IN MOUSE SCRAPIE
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DOI：
10.1016/0304-3940(89)90298-x
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发表时间：
1989-07-17
影响因子：
2.5
通讯作者：
FARQUHAR, CF
中科院分区：
文献类型：
--
作者：
BRUCE, ME;MCBRIDE, PA;FARQUHAR, CF
PrP蛋白的广泛免疫染色在痒病小鼠脑中得到证实，其广泛分布于神经纤维网中并集中分布于淀粉样蛋白斑、小胶质细胞和类似于神经元突起的2-5μm结构中。对于在特定区域产生局灶性空泡的 87V 瘙痒病株，PrP 病理学精确地针对这些相同区域，提前至少几周出现空泡变性。另一方面，ME7 瘙痒病株的空泡和 PrP 变化广泛分布在整个大脑中。 PrP 病理学的精确靶向以及随后的空泡变性很可能反映了传染原的潜在靶向和局部复制。
Widespread immunostaining of PrP protein was demonstrated in scrapie mouse brain, distributed diffusely in the neuropil and focally in amyloid plaques, microglia and 2-5 .mu.m structures resembling neuronal processes. With the 87V scrapie strain, which produces focal vacoulation in particular areas, PrP pathology was precisely targeted to these same areas, predating vacuolar degeneration by at least weeks. On the other hand, both vacuolar and PrP changes were widely distributed throughout the brain with the ME7 scrapie strain. It is likely that the precise targeting of PrP pathology, followed by vacuolar degeneration, reflects an underlying targeting and localised replication of infectious agent.