A combination of Tween 80 with CaCl2 enhances the hypocholesterolemic activity of bile salt hydrolase-active Lactobacillus casei F0422 in rats fed a cholesterol-rich diet
A combination of Tween 80 with CaCl2 enhances the hypocholesterolemic activity of bile salt hydrolase-active Lactobacillus casei F0422 in rats fed a cholesterol-rich diet
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Tween 80 与 CaCl2 的组合可增强饲喂富含胆固醇饮食的大鼠中具有胆汁盐水解酶活性的干酪乳杆菌 F0422 的降胆固醇活性
DOI：
10.1016/j.jff.2014.04.014
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发表时间：
2014-07-01
影响因子：
5.6
通讯作者：
Li, Jing-Yan
中科院分区：
文献类型：
--
作者：
Guo, Chun-Feng;Li, Jing-Yan
研究了吐温80和氯化钙混合物对胆盐水解酶（BSH）活性干酪乳杆菌F0422降胆固醇活性的影响。该混合物显著增强了菌株F0422在大鼠中的降胆固醇活性。与仅补充菌株F0422或吐温80和CaCl 2混合物的饮用水给药组相比，补充菌株F0422和吐温80和CaCl 2混合物的饮用水给药组的血清总胆固醇、低密度脂蛋白胆固醇和肝脏总胆固醇水平显著降低。Tween 80和CaCl2的混合物的组合菌株F0422的降胆固醇活性归因于通过Tween 80增强菌株F0422的胆汁盐耐受性和BSH催化活性以及CaCl2上调菌株F0422对肠上皮细胞的粘附而增加粪便胆汁酸排泄。(C)2014爱思唯尔有限公司版权所有。
The effects of a Tween 80 and CaCl2 mixture on the hypocholesterolemic activity of bile salt hydrolase (BSH)-active Lactobacillus casei F0422 were investigated in rats fed a cholesterol-rich diet for 3 weeks. This mixture significantly enhanced the hypocholesterolemic activity of strain F0422 in rats. The group administered drinking water supplemented with both strain F0422 and the Tween 80 and CaCl2 mixture had significantly lower levels of total serum cholesterol, low-density lipoprotein cholesterol and total liver cholesterol than did the group administered drinking water supplemented only with strain F0422 or the Tween 80 and CaCl2 mixture. The hypocholesterolemic activity of the combined strain F0422 and Tween 80 and CaCl2 mixture was attributed to the increase in fecal bile acid excretion through enhancement of bile salt tolerance and BSH catalytic activity of strain F0422 by Tween 80 and up-regulation of the adhesion of strain F0422 to intestinal epithelial cells by CaCl2. (C) 2014 Elsevier Ltd. All rights reserved.