Effect of mechanical stimuli on skeletal regeneration around implants
Effect of mechanical stimuli on skeletal regeneration around implants
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DOI：
10.1016/j.bone.2006.10.027
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发表时间：
2007-04-01
期刊：
影响因子：
4.1
通讯作者：
Heims, Jill A.
中科院分区：
文献类型：
--
作者：
Leucht, Philipp;Kim, Jae-Beom;Heims, Jill A.
由于人口老龄化和全关节置换的需求不断增加，骨整合引起了各个临床学科的极大兴趣。我们的目标是研究这一过程的分子和细胞基础。在这里，我们使用体内小鼠模型来研究卸载植入物三个不同区域的细胞和分子反应：骨膜、植入物和皮质骨之间的间隙以及骨髓空间。我们的分析从愈合的早期阶段开始，一直持续到种植体完全骨整合。我们研究了骨整合的各个方面，包括血管形成、细胞增殖、分化和骨重塑。通过这样做，我们了解了卸载种植体骨整合过程中不同骨骼组织的愈合机制。为了继续我们的分析，我们使用微动装置对种植体施加特定的物理刺激，这样，我们就显着增强了种植体周围组织的骨形成。通过将应变测量与细胞和分子分析进行比较，我们了解了应变大小与塑造骨骼再生的细胞的命运决定之间的相关性。 (c) 2006 Elsevier Inc. 保留所有权利。
Due to the aging population and the increasing need for total joint replacements, osseointegration is of a great interest for various clinical disciplines. Our objective was to investigate the molecular and cellular foundation that underlies this process. Here, we used an in vivo mouse model to study the cellular and molecular response in three distinct areas of unloaded implants: the periosteum, the gap between implant and cortical bone, and the marrow space. Our analyses began with the early phases of healing, and continued until the implants were completely osseointegrated. We investigated aspects of osseointegration ranging from vascularization, cell proliferation, differentiation, and bone remodeling. In doing so, we gained an understanding of the healing mechanisms of different skeletal tissues during unloaded implant osseointegration. To continue our analysis, we used a micromotion device to apply a defined physical stimulus to the implants, and in doing so, we dramatically enhanced bone formation in the peri-implant tissue. By comparing strain measurements with cellular and molecular analyses, we developed an understanding of the correlation between strain magnitudes and fate decisions of cells shaping the skeletal regenerate. (c) 2006 Elsevier Inc. All rights reserved.