Mice that "conditionally" lack basophils, AT LAST.
Mice that "conditionally" lack basophils, AT LAST.
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“有条件”缺乏嗜碱性粒细胞的小鼠终于出现了。
DOI：
10.1172/jci44058
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Min,Booki
中科院分区：
文献类型：
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作者：
Min,Booki
嗜碱性粒细胞是血液循环中含量最少的粒细胞。直到最近，人们对它们的功能还知之甚少。在过去的几年里，嗜碱性细胞在免疫方面的功能急剧增加。因此，需要嗜碱性细胞缺乏的动物模型来证实这些发现是必要的。在这一期的jci中，Wada及其同事介绍了第一个在体内条件消融嗜碱性细胞的小鼠模型。利用这个模型，他们揭示了嗜碱性细胞在获得性免疫对抗蜱虫感染中的非冗余作用。
Basophils are the least abundant granulocytes found in the circulation. Until recently, their functions were poorly understood. In the past few years, the list of basophil functions in the context of immunity has dramatically increased. Thus, the need for basophil-deficient animal models to confirm these findings is imperative. In this issue of theJCI, Wada and colleagues introduce the first mouse model in which basophils are conditionally ablated in vivo. Using this model, they then uncover a nonredundant role for basophils in acquired immunity against tick infection.