Matrix metalloproteinase-9 is a prognostic marker for patients with cervical cancer
Matrix metalloproteinase-9 is a prognostic marker for patients with cervical cancer
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基质金属蛋白酶-9是宫颈癌患者的预后标志物
DOI：
10.1007/s12032-012-0283-z
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发表时间：
2012-12-01
期刊：
影响因子：
3.4
通讯作者：
Yin, Guowu
中科院分区：
文献类型：
--
作者：
Li, Yi;Wu, Tao;Yin, Guowu
宫颈癌是女性最常见的恶性肿瘤之一。已有研究表明MMP-9可能是多种人类恶性肿瘤的预后标志物。本研究旨在探讨MMP-9蛋白在宫颈癌组织中的表达及其与临床病理特征和患者预后的关系。收集了225例术前未接受化疗或放疗的宫颈癌标本。免疫组化法检测MMP-9蛋白表达。结果显示，MMP-9在宫颈癌中表达增高，并与间质浸润、FIGO分期、淋巴结转移和血管浸润有关。Kaplan-Meier分析显示MMP-9阳性的宫颈癌患者的总生存率更低。在已知预后变量分层的多因素分析中，MMP-9被证明是一个独立的预后因素。本研究证实MMP-9在宫颈癌中的表达是影响患者预后的独立因素，可能成为宫颈癌诊断甚至治疗的潜在靶点。
Cervical cancer remains one of the most common malignancies in women. Previous study proved MMP-9 might be prognostic marker for multiple human malignancies. The present study was to investigate the protein expression of MMP-9 in cervical cancer and its association with clinicopathological characteristics as well as prognosis of patients. Cervical cancer specimens from 225 cases who had not received chemotherapy or radiotherapy prior to surgery were collected. Immunochemistry assays were utilized to investigate MMP-9 protein expression. Results showed that MMP-9 expression was increased in cervical cancer and associated with stromal invasion, FIGO stage, lymph node metastasis, and vascular invasion. Kaplan–Meier analysis showed that patients with cervical cancer of positive MMP-9 staining tend to have worse overall survival. In multivariate analysis stratified for known prognostic variables, MMP-9 was proved to be an independent prognostic factor. The present study confirmed that MMP-9 expression in cervical cancer was an independent prognostic factor of patients, which might be a potential diagnostic and even therapeutic target of cervical cancer.