Predictors of the Acute Postprandial Response to Breaking Up Prolonged Sitting
Predictors of the Acute Postprandial Response to Breaking Up Prolonged Sitting
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DOI：
10.1249/mss.0000000000002249
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发表时间：
2020-06-01
期刊：
影响因子：
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通讯作者：
Yates, Thomas
中科院分区：
文献类型：
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作者：
Henson, Joseph;Edwardson, Charlotte L.;Yates, Thomas
目的：确定站立或低强度体力活动中断久坐后餐后胰岛素和血糖水平有利变化的预测因素。方法数据来自4项设计相似的随机急性交叉试验（n = 129;体重指数[BMI]范围为19.6-44.6 kg中心点m（-2）;南亚人= 31.0%;失调= 27.1%）。治疗包括：久坐（6.5小时）或久坐中断站立或轻度体力活动（每30分钟5分钟）。计算每种治疗的胰岛素和葡萄糖的时间平均餐后反应（平均值+/- 95%置信区间）。使用相互校正的相互作用项检查人体测量（BMI）、人口统计学（年龄、性别、种族[白色欧洲人vs南亚人]）和心脏代谢变量（胰岛素抵抗稳态模型评估）是否修改了反应。结果：当个体因轻度体力活动而中断久坐时，餐后胰岛素和血糖降低，而站立时则无此变化。与白色欧洲人相比，南亚人的餐后胰岛素时间平均值的降低更为明显（-18.9 mU中心点L-1 [-23.5%] vs -8.2 mU中心点L-1 [-9.3%]），女性与男性相比（-15.0 mU中心点L-1 [-21.2%] vs -12.1 mU中心点L-1 [-17.6%]）或BMI >= 27.2 kg中心点m（-2）（-20.9 mU中心点L-1 [-22.9%] vs -8.7 mU中心点L-1 [-18.2%]）。同样，作为女性，（-0.4 mmol中心点L-1 [-0.6 mmol中心点L-1，-0.2 mmol中心点L-1]，-6.8% vs -0.1 mmol中心点L-1 [-0.3 mmol中心点L-1，1 mmol中心点L-1]，-1.7%）或BMI >= 27.2 kg中心点m（-2）（-0.4 mmol中心点L-1 [-0.6 mmol中心点L-1，-0.2 mmol中心点L-1]，-6.7% vs -0.2 mmol中心点L-1 [-0.4 mmol中心点L-1，0.0 mmol中心点L-1]，-3.4%）改变餐后血糖反应。胰岛素抵抗的稳态模型评估或年龄没有发现显著的相互作用。结论：女性、南亚人或BMI较高者，餐后胰岛素降低幅度较大，而女性和BMI较高者，在轻度体力活动中断坐位时，餐后血糖降低幅度较大。这些结果可能有助于指导高风险参与者的个性化干预，对于他们来说，通过轻度活动打破长时间的坐姿可能会产生最大的治疗潜力。
PurposeTo identify predictors of favorable changes to postprandial insulin and glucose levels in response to interrupting prolonged sitting time with standing or light-intensity physical activity. MethodsData were combined from four similarly designed randomized acute cross-over trials (n = 129; body mass index [BMI] range, 19.6-44.6 kg center dot m(-2); South Asian = 31.0%; dysglycemia = 27.1%). Treatments included: prolonged sitting (6.5 h) or prolonged sitting broken-up with either standing or light-intensity physical activity (5 min every 30 min). Time-averaged postprandial responses for insulin and glucose were calculated for each treatment (mean +/- 95% confidence interval). Mutually adjusted interaction terms were used to examine whether anthropometric (BMI), demographic (age, sex, ethnicity [white European vs South Asian]) and a cardiometabolic variable (Homeostatic Model Assessment of Insulin Resistance)-modified responses. ResultsPostprandial insulin and glucose were reduced when individuals interrupted prolonged sitting with bouts of light physical activity, but not with standing. Reductions in time-averaged postprandial insulin were more pronounced if individuals were South Asian compared with white European (-18.9 mU center dot L-1 [-23.5%] vs -8.2 mU center dot L-1 [-9.3%]), female compared with male (-15.0 mU center dot L-1 [-21.2%] vs -12.1 mU center dot L-1 [-17.6%]) or had a BMI >= 27.2 kg center dot m(-2) (-20.9 mU center dot L-1 [-22.9%] vs -8.7 mU center dot L-1 [-18.2%]). Similarly, being female (-0.4 mmol center dot L-1 [-0.6 mmol center dot L-1, -0.2 mmol center dot L-1], -6.8% vs -0.1 mmol center dot L-1 [-0.3 mmol center dot L-1, 1 mmol center dot L-1], -1.7%) or having a BMI >= 27.2 kg center dot m(-2) (-0.4 mmol center dot L-1 [-0.6 mmol center dot L-1, -0.2 mmol center dot L-1], -6.7% vs -0.2 mmol center dot L-1 [-0.4 mmol center dot L-1, 0.0 mmol center dot L-1], -3.4%) modified the postprandial glucose response. No significant interactions were found for Homeostatic Model Assessment of Insulin Resistance or age. ConclusionsBeing female, South Asian, or having a higher BMI, all predicted greater reductions in postprandial insulin, whereas being female and having a higher BMI predicted greater reductions in postprandial glucose when sitting was interrupted with light physical activity. These results could help to guide personalized interventions in high-risk participants for whom breaking prolonged sitting time with light activity may yield the greatest therapeutic potential.