A new alloantigen expressed selectively on B cells: the Lyb-2 system
A new alloantigen expressed selectively on B cells: the Lyb-2 system
复制标题
在 B 细胞上选择性表达的新同种抗原：Lyb-2 系统
作者：
H. Sato;E. A. Boyse
本文描述了小鼠新的同种异体抗原系统--LYB-2-，并记录了表型LYB-2.1的菌株分布。到目前为止，还没有针对替代LYB-2.2或其他表型的抗血清。目前证据表明，以LYB-2.1抗原为代表的细胞表面成分仅在B淋巴细胞系的细胞上表达。LYB-2.1抗血清对脾细胞的细胞毒效价可超过1：640，最大裂解效价通常在1：80左右。在两个LYB-2.1+小鼠亚系CBA/J和C3Hf/Bi中，脾细胞的裂解率低于其他LYB-2.1+株。Lyb-2基因座的位置尚未找到，但排除了与几个基因座的紧密连锁。
The new alloantigenic system of the mouse -Lyb-2-is described, and the strain distribution of the phenotype Lyb-2.1 recorded. So far no antiserum to the alternative Lyb-2.2 or other phenotypes is available. On present evidence, the cell-surface component represented by Lyb-2.1 antigen is expressed only on cells of the B-lymphocyte lineage. Cytotoxicity titers of Lyb-2.1 antisera may exceed 1:640 against spleen cells, with maximal lysis usually around 1:80. In two Lyb-2.1+ mouse sublines — CBA/J and C3Hf/Bi — the proportion of spleen cells lysed is lower than in other Lyb-2.1+ strains. The position of theLyb-2 locus has not been found, but close linkage with several loci has been excluded.