Improving catalyst scope: use of multiple aniline substrates to optimize a palladium-catalyzed bisdiene cyclization.
Improving catalyst scope: use of multiple aniline substrates to optimize a palladium-catalyzed bisdiene cyclization.
复制标题
改善催化剂范围：使用多种苯胺底物来优化钯催化的双二烯环化。
DOI：
10.1021/ol0488791
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Han,Jianxin
中科院分区：
文献类型：
--
作者：
Takacs,JamesM;Han,Jianxin
五种催化剂前体和九种配体与三种取代苯胺捕获试剂的组合筛选揭示了一种催化剂系统，该系统促进了一系列具有不同空间和电子特征的取代苯胺的有效钯催化环化-捕获。并行优化研究的结果说明了关键反应变量的相互依赖性。
Combinatorial screening of five catalyst precursors and nine ligands with three substituted aniline trapping reagents uncovered a catalyst system that promotes efficient palladium-catalyzed cyclization−trapping with a series of substituted anilines of varying steric and electronic character. The results of the parallel optimization study illustrate the interdependency of the key reaction variables.