ENKEPHALIN-LIKE IMMUNOREACTIVITY IN THE HUMAN GASTROINTESTINAL TRACT
ENKEPHALIN-LIKE IMMUNOREACTIVITY IN THE HUMAN GASTROINTESTINAL TRACT
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人类胃肠道中的脑啡肽样免疫反应
DOI：
10.1016/s0140-6736(77)92277-2
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发表时间：
1977
期刊：
影响因子：
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通讯作者：
A. Pearse
中科院分区：
文献类型：
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作者：
J. Polak;S. Bloom;S. Sullivan;P. Facer;A. Pearse
吗啡对大脑和肠道有很强的作用。已知具有阿片样作用的肽（内啡肽、脑啡肽）是大脑的正常成分，现在脑啡肽样免疫反应性已在肠道中显示。脑啡肽样免疫反应性存在于肠道的所有区域，胃窦中的浓度特别高，小肠上部的浓度显著。1 μm连续切片的免疫细胞化学显示，胃窦粘膜的许多细胞、十二指肠粘膜和胰腺的少数细胞、胆囊的肌间神经丛、胆囊管、胆管和下肠的其他区域中存在脑啡肽样免疫反应性。胃肠生理学似乎部分地受局部作用激素的调节，脑啡肽可能是其中之一。吗啡对消化道的既定作用为脑啡肽可能的生理作用提供了线索。
Morphine has powerful actions on brain and gut. Peptides with opiate-like actions (endorphins, enkephalins) are known to be normal constituents of the brain and now enkephalin-like immunoreactivity has been shown in the gut. Enkephalin-like immunoreactivity was present in all areas of the gut with particularly high concentration in the antrum and significant amounts in the upper small intestine. Immunocytochemistry on 1 μm serial sections revealed enkephalin-like immunoreactivity in numerous cells of the antral mucosa, in a few cells of the duodenal mucosa and pancreas, and in the myenteric plexus of the gall-bladder, cystic ducts, bileduct, and other areas of the lower intestine. Gastrointestinal physiology appears to be partly regulated by locally acting hormones, and enkephalin may be one of these. The established effects of morphine on the alimentary tract provide a clue to the possible physiological role of enkephalin.