Generalized epilepsy and classic spike-wave discharges with unilateral thalamic lesions
Generalized epilepsy and classic spike-wave discharges with unilateral thalamic lesions
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DOI：
10.1001/archneur.63.9.1321
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发表时间：
2006-09-01
影响因子：
--
通讯作者：
Cossette, Patrick
中科院分区：
文献类型：
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作者：
Nguyen, Dang K.;Podubnaia, Ala B.;Cossette, Patrick
背景：特发性全身性癫痫（IGE）是一种异质性疾病，主要是遗传起源。IGE综合征的临床标志包括全身棘波和波放电和正常结果的脑imaging. Objective：描述2例临床表现与IGE兼容，但其影像学研究显示单侧丘脑insure.Design：病例报告。患者：两个21岁的patients（1男1女）. Main Outcome Measures：Magnetic Resonance Imaging Findings. Results：Magnetic Resonance Imaging Unexpected Revealed单侧丘脑lesions. Conclusions：我们建议在IGE患者中进行磁共振成像研究，特别是在难治性或非典型病例中。在极少数情况下，IGE的临床特征可能与结构性丘脑或其他病变相关。
Background: Idiopathic generalized epilepsy (IGE) is a heterogeneous condition with a predominantly genetic origin. Clinical hallmarks of IGE syndromes include generalized spike and wave discharges and normal results on brain imaging.Objective: To describe 2 patients with clinical presentations compatible with IGE but whose imaging studies revealed unilateral thalamic lesions.Design: Case reports.Setting: University-affiliated hospitals. Patients: Two 21-year-old patients (1 man and 1 woman).Main Outcome Measures: Magnetic resonance imaging findings.Results: Magnetic resonance imaging unexpectedly revealed unilateral thalamic lesions.Conclusions: We recommend doing magnetic resonance imaging studies in patients with IGE, especially in refractory or atypical cases. In rare cases, clinical features compatible with IGE may be associated with structural thalamic or other lesions.