Progression of corpus callosum atrophy in Alzheimer disease
Progression of corpus callosum atrophy in Alzheimer disease
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DOI：
10.1001/archneur.59.2.243
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发表时间：
2002-02-01
影响因子：
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通讯作者：
Hampel, H
中科院分区：
文献类型：
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作者：
Teipel, SJ;Bayer, W;Hampel, H
背景：阿尔茨海默病（AD）的胼胝体萎缩在没有原发性白质变性的情况下反映了皮层内突出的新皮层锥体神经元的丢失。目的：确定阿尔茨海默病患者胼胝体萎缩进展的个体率，并将萎缩进展率与临床疾病严重程度和皮层下疾病联系起来。方法：对21例临床诊断为AD的患者（平均观察时间17.0 +/- 8.5个月）和10例年龄和性别匹配的健康对照（平均观察时间24.1 +/- 6.8个月）的胼胝体大小进行磁共振成像纵向测量。结果：AD患者的胼胝体大小在基线时显著减小。阿尔茨海默病患者胼胝体、脾和脑坛的年总萎缩率（分别为-7.7%、-12.1%和-7.3%）明显高于对照组（分别为-0.9%、-1.5%和0.6%）。阿尔茨海默病患者脾胼胝体萎缩率与痴呆严重程度进展相关(p = 0.52, p
Background: Atrophy of the corpus callosum in the absence of primary white matter degeneration reflects loss of intracortical projecting neocortical pyramidal neurons in Alzheimer disease (AD).Objectives: To determine individual rates of atrophy progression of the corpus callosum in patients with AD and to correlate rates of atrophy progression with clinical disease severity and subcortical disease.Methods: Magnetic resonance imaging-derived measurements of corpus callosum size were studied longitudinally in 21 patients clinically diagnosed as having AD (mean observation time, 17.0 +/- 8.5 months) and 10 age-and sex-matched healthy controls (mean observation time, 24.1 +/- 6.8 months).Results: Corpus callosum size was significantly reduced in AD patients at baseline. Annual rates of atrophy of total corpus callosum, splenium, and rostrum were significantly larger in AD patients (-7.7%, -12.1%, and -7.3%, respectively) than in controls (-0.9%, -1.5%, and 0.6%, respectively). Rates of atrophy of the corpus callosum splenium were correlated with progression of dementia severity in AD patients (p = 0.52, P