Rainbow of KIBOU (ROK) study: a Breast Cancer Survivor Cohort in Japan.
Rainbow of KIBOU (ROK) study: a Breast Cancer Survivor Cohort in Japan.
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DOI：
10.1007/s12282-017-0784-x
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发表时间：
2018-01
期刊：
影响因子：
--
通讯作者：
Yamamoto S
中科院分区：
文献类型：
--
作者：
Mizota Y;Ohashi Y;Iwase T;Iwata H;Sawaki M;Kinoshita T;Taira N;Mukai H;Yamamoto S
尽管有大量流行病学研究探讨生活方式因素在乳腺癌中的病因作用，但关于生活方式因素与乳腺癌预后之间关系的研究却很少。为了调查饮食和身体活动等生活方式因素、补充和替代医学的使用以及心理社会因素对预后的影响，我们设计了一项针对日本女性乳腺癌患者的大规模队列研究。计划样本量为 7200 个。该队列是与多项临床试验、癌症登记和日常实践合作进行的。有关临床因素、治疗和随访的信息将从临床试验和参与医院获得。在手术前、手术后立即或手术后 1 至 5 年向受试者提供一份自填问卷。还收集血液和组织样本。主要终点是无病生存期。次要终点是总体生存率和健康相关的生活质量。跟进期为最后一位参与者注册后至少 5 年。招募于2007年11月开始。截至2017年4月，已有5852名患者以及1430个生物样本参与了该研究，该研究仍在进行中。参与该研究的受试者数量已经是世界上最多的。韩国的研究将为乳腺癌的生存提供许多重要的证据。
Although there are a large number of epidemiological studies investigating the etiological role of lifestyle factors in breast cancer, there are few studies on the association between lifestyle factors and breast cancer prognosis. To investigate the influence of lifestyle factors such as diet and physical activity, use of complementary and alternative medicine, and psychosocial factors on prognosis, we designed a large-scale cohort study of female breast cancer patients in Japan. The planned sample size is 7200. The cohort is being conducted in collaboration with several clinical trials, a cancer registry, and daily practice. Information on clinical factors, treatment, and follow-up will be obtained from the clinical trials and participating hospitals. A self-administered questionnaire is given to subjects before, immediately after, or 1 to 5 years after surgery. Blood and tissue samples are also collected. The primary endpoint is disease-free survival. The secondary endpoints are overall survival and health-related quality of life. The follow-up period will be at least 5 years after the last participant is enrolled. Recruitment began in November 2007. As of April 2017, there are 5852 patients enrolled in the study along with 1430 biological samples and the study is still ongoing. The number of subjects enrolled in the study is already the largest in the world. The ROK study will provide much important evidence for breast cancer survivorship.
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影响因子：
120.7
作者：
Shu, Xiao Ou;Zheng, Ying;Cai, Hui;Gu, Kai;Chen, Zhi;Zheng, Wei;Lu, Wei
通讯作者：
Lu, Wei
影响因子：
3.8
作者：
HERTH, K
通讯作者：
HERTH, K
影响因子：
3.3
作者：
Brooks, R
通讯作者：
Brooks, R
影响因子：
2.4
作者：
Sawaki, Masataka;Tokudome, Nahomi;Ohashi, Yasuo
通讯作者：
Ohashi, Yasuo
影响因子：
1.2
作者：
RADLOFF L S
通讯作者：
RADLOFF L S