New functional aspects of the extracellular calcium-sensing receptor.
New functional aspects of the extracellular calcium-sensing receptor.
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DOI：
10.1097/01.mnh.0000447016.21228.e0
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发表时间：
2014-07
影响因子：
3.2
通讯作者：
Toka HR
中科院分区：
文献类型：
--
作者：
Toka HR
细胞外钙水平的变化对肾功能有很大影响。所观察到的大多数效应归因于钙敏感受体（CaSR），这是一种广泛表达的G蛋白偶联细胞表面蛋白，在骨矿物质稳态中具有重要功能。这篇综述的目的是概括新的功能方面的CaSR。小鼠模型的结果推测CaSR在各种组织中具有重要功能。在肾脏中，CaSR的主要作用是调节粗升支中的钙重吸收，与其对甲状旁腺激素分泌的作用无关。CaSR调节密蛋白14，密蛋白14是与尿钙排泄相关的粗升支中细胞旁离子转运的守门人。CaSR改变紧密连接通透性的一种细胞内信号传导途径是钙调神经磷酸酶-NFAT 1c-microRNA-claudin 14轴。CaSR在肾脏中的主要功能是调节粗升支中的钙排泄，不依赖于甲状旁腺激素。CaSR通过改变紧密连接蛋白claudin 14的表达来调节细胞旁阳离子转运。还需要更多的工作来充分了解CaSR在肾脏中的所有功能。肾脏中钙“感应”的替代途径需要研究。
Variations in extracellular calcium level have a large impact on kidney function. Most of the effects seen are attributed to the calcium-sensing receptor (CaSR), a widely expressed G-protein-coupled cell surface protein with important function in bone mineral homeostasis. The purpose of this review is to recapitulate novel functional aspects of CaSR. Results from mouse models surmise important functions for CaSR in various tissues. In the kidney, the main role of CaSR is the regulation of calcium reabsorption in the thick ascending limb, independently of its role on parathyroid hormone secretion. CaSR modulates claudin 14, the gatekeeper of paracellular ion transport in the thick ascending limb that is associated with urinary calcium excretion. One intracellular signaling pathway by which CaSR alters tight junction permeability is the calcineurin-NFAT1c-microRNA-claudin14 axis. The main function of CaSR in the kidney is the regulation of calcium excretion in the thick ascending limb, independently of parathyroid hormone. CaSR modulates paracellular cation transport by altering expression of the tight junction protein claudin 14. Still more work is needed to fully understand all functions of CaSR in the kidney. Alternative pathways of calcium “sensing” in the kidney need to be investigated.
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影响因子：
7.3
作者：
Chang W;Tu C;Chen TH;Bikle D;Shoback D
通讯作者：
Shoback D
DOI：
10.1002/ajmg.b.30896
发表时间：
2009-07-05
影响因子：
2.8
作者：
Conley, Yvette P.;Mukherjee, Ankur;Kammerer, Candace;DeKosky, Steven T.;Kamboh, M. Ilyas;Finegold, David N.;Ferrell, Robert E.
通讯作者：
Ferrell, Robert E.
影响因子：
4
作者：
Faure, Helene;Gorojankina, Tatiana;Ruat, Martial
通讯作者：
Ruat, Martial
影响因子：
15.9
作者：
GILL, JR;BARTTER, FC
通讯作者：
BARTTER, FC
影响因子：
3.2
作者：
Harding, Brian;Curley, Alan J.;Thakker, Rajesh V.
通讯作者：
Thakker, Rajesh V.