RADIAL AND VERTEBRAL BONE-DENSITY IN WHITE AND BLACK-WOMEN - EVIDENCE FOR RACIAL-DIFFERENCES IN PREMENOPAUSAL BONE HOMEOSTASIS
RADIAL AND VERTEBRAL BONE-DENSITY IN WHITE AND BLACK-WOMEN - EVIDENCE FOR RACIAL-DIFFERENCES IN PREMENOPAUSAL BONE HOMEOSTASIS
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DOI：
10.1210/jcem-69-4-762
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发表时间：
1989-10-01
影响因子：
5.8
通讯作者：
GOLDSMITH, SJ
中科院分区：
文献类型：
--
作者：
LUCKEY, MM;MEIER, DE;GOLDSMITH, SJ
白色和黑人妇女的骨质疏松性骨折发生率不同的原因尚不清楚。以前的骨量种族比较受到体重和社会经济，健康和营养状况的种族差异的限制。本横断面研究采用腰椎双光子吸收法和桡骨远端单光子吸收法检测了105名黑人和114名白色健康非肥胖女性的骨密度，年龄24-65岁。在所有年龄段，黑人的两个部位的骨密度都高于白人。当调整年龄和体重指数后，黑人的脊柱和桡骨的平均骨密度要高出6.5%（P < 0.0001）。椎体骨密度下降的横截面率在不同种族之间相似;然而，46岁以下绝经前黑人的径向密度每十年增加3.8%（P = 0.03），而绝经前白人的径向密度每十年下降3.2%（P = 0.09）。这些绝经前妇女的斜率种族差异显著（P = 0.002）。这些发现表明，黑人女性达到较高的峰值骨量和延迟发生骨丢失有助于降低骨质疏松性骨折的发生率。
The reasons for a different incidence of osteoporotic fractures in white and black women are unknown. Previous racial comparisons of bone mass have been limited by racial differences in body weight and socioeconomic, health, and nutritional status. This cross-sectional study examined bone density in 105 black and 114 white healthy nonobese women, 24-65 yr old, using dual photon absorptiometry of the lumbar spine and single photon absorptiometry of the distal radius. Bone density at both sites was higher in blacks at all ages than in whites. When adjusted for age and body mass index, mean bone density was 6.5% higher in blacks at both spine and radius (P < 0.0001). The cross-sectional rate of decline of vertebral bone density was similar between races; however, radial density increased 3.8%/decade (P = 0.03) in premenopausal blacks under age 46 yr, while it declined 3.2%/decade (P = 0.09) in premenopausal whites. The racial difference in slopes in these premenopausal women is significant (P = 0.002). These findings suggest that attainment of higher peak bone mass and delayed onset of bone loss contribute to the lower incidence of osteoporotic fractures in black women.