Inflammatory response to implantation of transparent nanocrystalline yttria-stabilized zirconia using a dorsal window chamber model
Inflammatory response to implantation of transparent nanocrystalline yttria-stabilized zirconia using a dorsal window chamber model
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DOI：
10.1016/j.nano.2016.04.009
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发表时间：
2016-10-01
影响因子：
5.4
通讯作者：
Aguilar, Guillermo
中科院分区：
文献类型：
--
作者：
Damestani, Yasaman;Galan-Hoffman, Diego E.;Aguilar, Guillermo
大脑之窗 (WttB) 的长期目标是通过提供一种技术来改善患者护理，该技术可按需、大面积、长期重复地将光传输到大脑或从大脑收集光，而无需重复开颅手术。为了评估纳米晶氧化钇稳定氧化锆 (nc-YSZ) 颅骨植入物用于光学治疗和成像的潜力，使用背窗室模型研究了体内生物相容性，并与对照（无植入物）和市售颅骨植入材料（PEEK 和 PEKK）进行比较。通过使用透照和荧光显微镜测量两周内的白细胞粘附、血管直径、血流速率和血管通透性来表征宿主组织对植入物的反应。结果表明，在微观水平上，宿主组织对nc-YSZ没有炎症反应，这表明nc-YSZ是颅骨植入物的良好替代材料。 (C) 2016 Elsevier Inc. 保留所有权利。
The long-range goal of the windows to the brain ( WttB) is to improve patient care by providing a technique for delivery and/or collection of light into/from the brain, on demand, over large areas, and on a chronically-recurring basis without the need for repeated craniotomies. To evaluate the potential of nanocrystalline yttria-stabilized-zirconia ( nc-YSZ) cranial implant for optical therapy and imaging, in vivo biocompatibility was studied using the dorsal window chamber model in comparison with control ( no implant) and commercially available cranial implant materials ( PEEK and PEKK). The host tissue response to implant was characterized by using transillumination and fluorescent microscopy to measure leukocyte adhesion, blood vessel diameter, blood flow rate, and vascular permeability over two weeks. The results indicated the lack of inflammatory reaction of the host tissue to nc-YSZ at the microscopic level, suggesting that nc-YSZ is a good alternative material for cranial implants. (C) 2016 Elsevier Inc. All rights reserved.