Obesity and regional body-fat distribution in men: separate and joint relationships to glucose tolerance and plasma lipoproteins.
Obesity and regional body-fat distribution in men: separate and joint relationships to glucose tolerance and plasma lipoproteins.
复制标题
男性肥胖和局部体脂肪分布：与葡萄糖耐量和血浆脂蛋白的单独和联合关系。
DOI：
10.1093/ajcn/60.5.682
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
O. Bosello
中科院分区：
文献类型：
--
作者：
M. Zamboni;F. Armellini;L. Cominacini;E. Turcato;T. Todesco;L. Bissoli;R. Micciolo;I. Bergamo;O. Bosello
在35名男性中研究了通过计算机断层扫描和代谢变量评估的肥胖和脂肪分布之间的关系。体重指数与口服葡萄糖负荷期间的葡萄糖总和和HDL 3甘油三酯之间以及内脏腹部脂肪与甘油三酯、载脂蛋白B、口服葡萄糖负荷期间的胰岛素总和、极低密度脂蛋白（VLDL）胆固醇以及VLDL和低密度脂蛋白（LDL）甘油三酯之间出现显著相关性。内脏腹部脂肪与高密度脂蛋白与低密度脂蛋白胆固醇的比率呈负相关。当受试者根据体重指数（<或= 26.7，> 26.7）和腹部内脏脂肪中位数被分成四组时，体重指数没有发现显著差异，而甘油三酯、胆固醇、载脂蛋白B、VLDL胆固醇、HDL：LDL胆固醇和VLDL甘油三酯存在显著差异。我们的研究表明，内脏腹部脂肪的量是代谢异常的最相关因素。我们的数据还表明，内脏脂肪的影响与体重指数无关。
Relationships between obesity and fat distribution as evaluated by computed tomography and metabolic variables were studied in 35 men. Significant correlations emerged between body mass index and sum of glucose during oral glucose load and HDL3 triglycerides and also between visceral abdominal fat and triglycerides, apolipoprotein B, sum of insulin during oral glucose load, very-low-density-lipoprotein (VLDL) cholesterol, and VLDL and low-density-lipoprotein (LDL) triglycerides. Visceral abdominal fat correlated negatively with the ratio of HDL to LDL cholesterol. When the subjects were subdivided into four groups according to body mass index (< or = 26.7, > 26.7) and median visceral abdominal fat, no significant differences were found in body mass index, whereas significant differences were found for triglycerides, cholesterol, apolipoprotein B, VLDL cholesterol, HDL:LDL cholesterol, and VLDL triglycerides. Our study shows that the amount of visceral abdominal fat is the most relevant factor for metabolic abnormalities. Our data also suggest that the effect of visceral fat is independent of body mass index.