18F-FDG-PET of musculoskeletal tumors: a correlation with the expression of glucose transporter 1 and hexokinase II
18F-FDG-PET of musculoskeletal tumors: a correlation with the expression of glucose transporter 1 and hexokinase II
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DOI：
10.1007/s12149-008-0173-9
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发表时间：
2008-10-01
影响因子：
2.6
通讯作者：
Hatazawa, Jun
中科院分区：
文献类型：
--
作者：
Hamada, Kenichiro;Tomita, Yasuhiko;Hatazawa, Jun
2-脱氧-2-[F-18]氟-d-葡萄糖(F-18-FDG)正电子发射断层扫描(PET)能否鉴别肌肉骨骼肿瘤的良、恶性仍存在争议。为了揭示F-18-FDG积聚的机制，我们分析了良性和恶性肌肉骨骼肿瘤中F-18-FDG积聚与葡萄糖转运蛋白1(GLUT-1)和己糖激酶II(HK-II)表达的相关性。将24例良性和26例恶性肌肉骨骼肿瘤的F-18-FDG的最大标准摄取值(SUVmax)与组织学恶性肿瘤进行了比较，并用免疫组织化学方法分析了GLUT-1和HK-II的表达。恶性肿瘤的SUVmax(6.33+/-4.79)显著高于良性肿瘤(3.47+/-123.79)P<；0.01)。GLUT-1高表达12例(均为恶性)，低表达38例(良性24例，恶性14例)，HK-II高表达36例(良性11例，恶性25例)，低表达14例(良性13例，恶性1例)。免疫组化GLUT-1和HK-II高表达组的SUVmax明显高于低表达组(GLUT-1 8.03+/-5.10和3.98+/-3.53，P<；0.01；HK-II 5.73+/-4.49和2.99+/-3.02，P<；0.01)。F-18FDG的SUVmax对于良、恶性肿瘤的鉴别诊断以及GLUT-1和HK-II的表达没有明显的区分阈值。F-18FDG-PET对肌肉骨骼肿瘤的鉴别诊断能力有限，部分原因是单个肿瘤中GLUT-1和HK-II的表达水平不同。
It remains controversial whether positron emission tomography (PET) with 2-deoxy-2-[F-18]fluoro-d-glucose (F-18-FDG) can differentiate between benign and malignant musculoskeletal tumors. To uncover the mechanism of F-18-FDG accumulations, we analyzed the correlation between the F-18-FDG accumulation and the expression of glucose transporter 1 (Glut-1) and hexokinase II (HK-II) in benign and malignant musculoskeletal tumors.The maximum standardized uptake values (SUVmax) of F-18-FDG in 24 benign and 26 malignant musculoskeletal tumors were compared with the histologic malignancies, and the expression of Glut-1 and HK-II was analyzed by immunohistochemistry.The SUVmax for malignant tumors (6.33 +/- 4.79) was significantly higher than those with benign tumors (3.47 +/- 3.12, P < 0.01). The expression of Glut-1 was high in 12 patients (all malignant) and low in 38 patients (24 benign and 14 malignant), and the expression of HK-II was high in 36 patients (11 benign and 25 malignant) and low in 14 patients (13 benign and 1 malignant). Cases with high expression of Glut-1 and HK-II at immunohistochemistry showed a higher SUVmax than those with low expression (Glut-1 8.03 +/- 5.10 and 3.98 +/- 3.53, P < 0.01; HK-II 5.73 +/- 4.49 and 2.99 +/- 3.02, P < 0.01). No significant dividing threshold of the SUVmax of F-18 FDG was found for the differential diagnosis between benign and malignant tumors or for the expression of Glut-1 and HK-II.The limited capability of F-18 FDG-PET in the differential diagnosis of musculoskeletal tumors is owing partly to the various levels of Glut-1 and HK-II expression in individual tumors.