MPTP mouse models of Parkinson's disease: an update.
MPTP mouse models of Parkinson's disease: an update.
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DOI：
10.3233/jpd-2011-11023
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Rademacher DJ
中科院分区：
文献类型：
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作者：
Meredith GE;Rademacher DJ
Among the most widely used models of Parkinson’s disease (PD) are those that employ toxins, especially 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Depending on the protocol used, MPTP yields large variations in nigral cell loss, striatal dopamine loss and behavioral deficits. Motor deficits do not fully replicate those seen in PD. Nonetheless, MPTP mouse models mimic many aspects of the disease and are therefore important tools for understanding PD. In this review, we will discuss the ability of MPTP mouse models to replicate the pathophysiology of PD, the mechanisms of MPTP-induced neurotoxicity, strain differences in susceptibility to MPTP, and the models’ roles in testing therapeutic approaches.
