Update in respiratory infections 2011.
Update in respiratory infections 2011.
复制标题
2011 年呼吸道感染最新情况。
DOI：
10.1164/rccm.201203-0540up
复制
发表时间：
2012
影响因子：
24.7
通讯作者：
Niederman,MichaelS
中科院分区：
文献类型：
--
作者：
Wunderink,RichardG;Niederman,MichaelS
Respiratory tract infections again featured prominently in the Journal and other publications in 2011. We will discuss updates in respiratory tract infections, classified by the traditional breakdowns by site of acquisition, type of infection, and to a certain extent, causative organisms. Publications addressing cystic fibrosis are the subject of a separate update. Full understanding of infections of the lower respiratory tract requires knowledge of the normal flora of the respiratory tract. An extremely careful study of the distal lung microbiota (sampled by bronchoalveolar lavage and protected specimen brush) in healthy volunteers contradicts the general assumption that the distal lung is sterile. After careful control for contamination of the bronchoscope during insertion, Charlson and colleagues found that the distal respiratory tract contained an almost identical spectrum of bacteria as the upper respiratory tract but at roughly 2–4 logs lower quantitative counts (1). Distal lung–only isolates were rare and varied from person to person but did include pathogens associated with nosocomial pneumonia. Although study of the lung microbiome is just beginning, changes in the microbiome at this site are likely to have important effects on risk of pneumonia and possibly other respiratory illnesses, similar to those demonstrated for alterations in the gut microbiome (2).
