A novel method for assessing arterial endothelial function using phase contrast magnetic resonance imaging: vasoconstriction during reduced shear.
A novel method for assessing arterial endothelial function using phase contrast magnetic resonance imaging: vasoconstriction during reduced shear.
复制标题
使用相差磁共振成像评估动脉内皮功能的新方法：减少剪切期间的血管收缩。
DOI：
10.1081/jcmr-65578
复制
发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Lima,JoaoAC
中科院分区：
文献类型：
--
作者：
Silber,HarryA;Ouyang,Pamela;Bluemke,DavidA;Gupta,SandeepN;Foo,ThomasK;Lima,JoaoAC
我们研究了是否可以使用相位对比磁共振成像（PCMRI）测量在减少剪切内皮依赖性动脉收缩。在33名受试者的5分钟远端闭塞期间采集股动脉的横截面。通过最佳拟合抛物线从速度分布测量symptoms剪切速率和半径。袖带充气后即刻收缩压剪切率降低（404 ± 78至233 ± 75 sec-1，p < .0001）。在充盈2分钟时半径减小（3.52 ± 0.41 mm至3.43 ± 0.42 mm，p <0.0001）。总之，可以使用PCMRI测量血流减少期间的动脉收缩。这种新的方法可能会增加重要的信息对内皮功能的综合评价。
We investigated whether endothelial-dependent arterial constriction during reduced shear can be measured using phase contrast magnetic resonance imaging (PCMRI). A cross-section of the femoral artery was acquired during a 5-minute distal occlusion in 33 subjects. Systolic shear rate and radius were measured from the velocity profile via a best-fit parabola. Systolic shear rate decreased immediately after cuff inflation (404 ± 78 to 233 ± 75 sec− 1p < .0001). Radius decreased at 2 min into inflation (3.52 ± .41 to 3.43 ± .42 mm, p < .0001). In conclusion, arterial constriction during reduced flow can be measured using PCMRI. This new method may add important information toward a comprehensive evaluation of endothelial function.