Variability in atlas registration of optical intrinsic signal imaging and its effect on functional connectivity analysis.
Variability in atlas registration of optical intrinsic signal imaging and its effect on functional connectivity analysis.
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DOI：
10.1364/josaa.410447
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发表时间：
2021-02-01
期刊：
影响因子：
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通讯作者：
White BR
中科院分区：
文献类型：
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作者：
Padawer-Curry JA;Jahnavi J;Breimann JS;Licht DJ;Yodh AG;Cohen AS;White BR
为了比较受试者之间的神经成像数据，需要将来自各个会话的图像与公共参考或“图谱”对齐。例如，小鼠的光学固有信号成像的图谱配准通常使用仿射变换来执行，其中参数通过手动选择典型的颅骨界标来确定。这种程序所引起的错误以前没有调查过。我们量化的可变性，从这个过程中产生的不对齐，影响功能性神经影像数据的解释随之而来的错误。我们提出了一种改进的方法，使用单独获得的高分辨率图像，并证明使用这种方法的变异性和对齐的改进。
To compare neuroimaging data between subjects, images from individual sessions need to be aligned to a common reference or “atlas”. Atlas registration of optical intrinsic signal imaging of mice, for example, is commonly performed using affine transforms with parameters determined by manual selection of canonical skull landmarks. Errors introduced by such procedures have not previously been investigated. We quantify the variability that arises from this process and consequent errors from misalignment that affect interpretation of functional neuroimaging data. We propose an improved method, using separately-acquired high-resolution images, and demonstrate improvements in variability and alignment using this method.