PERIPHERAL OPIOID MODULATION OF PAIN AND INFLAMMATION IN THE FORMALIN TEST
PERIPHERAL OPIOID MODULATION OF PAIN AND INFLAMMATION IN THE FORMALIN TEST
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DOI：
10.1016/0014-2999(95)00045-m
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发表时间：
1995-04-13
影响因子：
5
通讯作者：
ABBOTT, FV
中科院分区：
文献类型：
--
作者：
HONG, YG;ABBOTT, FV
本文观察了局部应用阿片受体激动剂对大鼠足底注射1%福尔马林引起的早期（0-10 min）和晚期（20-40 min）行为反应及外渗的影响。μ-阿片受体激动剂[D-Ala（2），N-Me-Phe（4），Gly（5）-ol]脑啡肽（DAMGO）在晚期阶段抑制疼痛行为，并在两个阶段抑制外渗。κ-阿片受体激动剂反式-（+/-）-3，4-二氯-N-甲基-N-（2-[1-吡咯烷基]苯乙酰胺甲磺酸盐（U 50，488 H）抑制两个阶段的行为反应，但外渗在早期阶段增强，在晚期阶段没有改变。δ-阿片受体激动剂[D-Pen（2，5）]脑啡肽（DPDPE）增强晚期行为反应，但抑制早期和晚期外渗。全身注射激动剂没有影响，和预处理与s.c.纳洛酮甲碘化物逆转了局部给药激动剂的作用。这些数据（1）支持福尔马林试验两个阶段的基础是不同的病理生理机制的观点，（2）表明根据受体特异性，阿片受体激动剂具有促伤害感受和抗伤害感受作用，以及促伤害感受和抗伤害感受活性。
The effects of local treatment with opioid receptor agonists on the early (0-10 min) and late (20-40 min) behavioural response and extravasation induced by intraplantar injection of 1% formalin in rats were examined. The mu-opioid receptor agonist [D-Ala(2),N-Me-Phe(4),Gly(5)-ol]enkephalin (DAMGO) depressed pain behaviour in the late phase, and extravasation in both phases. The kappa-opioid receptor agonist trans-(+/-)-3,4-dichloro-N-methyl-N-(2-[1-pyrrolidinyl]benzeneacetamide methanesulfonate (U50,488H) suppressed the behavioural response in both phases, but extravasation was enhanced in the early phase and not altered in the late phase. The delta-opioid receptor agonist [D-Pen(2,5)]enkephalin (DPDPE) enhanced the behavioural response in the late phase, but inhibited extravasation in the both early and late phases. Systemic injection of the agonists had no effects, and pretreatment with s.c. naloxone methiodide reversed the effects of locally administered agonists. These data (1) support the notion that different pathophysiological mechanisms underlie the two phases of the formalin test, and (2) indicate that depending on the receptor specificity, opioid receptor agonists have both pro- and antinociceptive effects, as well as pro- and antiinflammatory activity.