IS THE ACETYLCHOLINE-RECEPTOR A RABIES VIRUS RECEPTOR
IS THE ACETYLCHOLINE-RECEPTOR A RABIES VIRUS RECEPTOR
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DOI：
10.1126/science.7053569
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发表时间：
1982-01-01
期刊：
影响因子：
56.9
通讯作者：
TIGNOR, GH
中科院分区：
文献类型：
--
作者：
LENTZ, TL;BURRAGE, TG;TIGNOR, GH
狂犬病病毒在小鼠横膈膜和培养的鸡肌管上的分布与乙酰胆碱受体的分布一致。用α-羟甲基纤维素处理肌管在加入病毒之前，银环蛇毒素和d-筒箭毒碱减少了感染狂犬病病毒的肌管的数量。这些发现共同表明，乙酰胆碱受体作为狂犬病病毒的受体。病毒与高密度存在于神经肌肉接头处的乙酰胆碱受体的结合将提供一种机制，由此病毒可以局部集中在邻近外周神经的部位，促进随后的摄取和转移到CNS。
Rabies virus was found on mouse diaphragms and on cultured chick myotubes in a distribution coinciding with that of the acetylcholine receptor. Treatment of the myotubes with .alpha.-bungarotoxin and d-tubocurarine before the addition of the virus reduced the number of myotubes that became infected with rabies virus. These findings together suggest that acetylcholine receptors serve as receptors for rabies virus. The binding of virus to acetylcholine receptors, which are present in high density at the neuromuscular junction, would provide a mechanism whereby the virus could be locally concentrated at sites in proximity to peripheral nerves, facilitating subsequent uptake and transfer to the CNS.