Association between the insulin-like growth factor 1 gene rs2195239 and rs2162679 polymorphisms and cancer risk: a meta-analysis
Association between the insulin-like growth factor 1 gene rs2195239 and rs2162679 polymorphisms and cancer risk: a meta-analysis
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胰岛素样生长因子 1 基因 rs2195239 和 rs2162679 多态性与癌症风险之间的关联：荟萃分析
DOI：
10.1186/s12881-019-0749-3
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发表时间：
2019-01-17
影响因子：
--
通讯作者：
Wu，Li-Fang
中科院分区：
文献类型：
--
作者：
Xu，Gui-Ping;Chen，Wei-Xian;Wu，Li-Fang
背景许多流行病学研究表明，胰岛素样生长因子1（IGF 1）基因单核苷酸多态性（SNPs）可能与癌症风险相关。在IGF1基因的几个常见多态性位点中，rs2195239和rs2162679引起了人们的广泛关注。因此，我们进行荟萃分析，以确定潜在的关联betweenIGF1rs2195239和rs2162679多态性和cancer risk.MethodsWe检索相关文章从PubMed，Embase和Web of Science数据库到2018年4月30日。最终，本荟萃分析纳入了13项研究，涉及12，515例病例和19，651例对照。结果rs2195239在纯合子模型中降低了总体癌症风险，在等位基因、纯合子和隐性模型中降低了亚洲人群的癌症风险。rs2195239与乳腺癌或胰腺癌风险之间没有显著关系。rs2162679在等位基因、纯合子、显性和隐性模型中降低了癌症的总体风险，在等位基因、纯合子和隐性模型中降低了亚洲人群的癌症风险。
BackgroundMany epidemiological studies have suggested that insulin-like growth factor1 (IGF1) gene single-nucleotide polymorphisms (SNPs) may be associated with cancer risk. Among several commonly studied polymorphisms inIGF1gene, rs2195239 and rs2162679 attracted many attentions. So we perform a meta-analysis to determine potential associations betweenIGF1rs2195239 and rs2162679 polymorphisms and cancer risk.MethodsWe retrieved relevant articles from the PubMed, Embase, and Web of Science databases up to April 30, 2018. Ultimately, thirteen studies were included in the present meta-analysis, which involved 12,515 cases and 19,651 controls. The odd ratios (ORs) and their 95% confidence intervals (CIs) were pooled to estimate the strength of the associations.Resultsrs2195239 reduces the overall cancer risk in homozygote model, as well as reducing cancer risk in Asian populations in allele, homozygote, and recessive models. No significant relationship was found between rs2195239 and breast or pancreatic cancer risk. rs2162679 reduces the overall cancer risk in allele, homozygote, dominant, and recessive models, as well as reducing cancer risk in Asian populations in allele, homozygote, and recessive models.ConclusionsIGF1rs2195239 and rs2162679 were associated with overall cancer risk based on present studies.