Potential Consumers' Attitudes Toward Psychiatric Genetic Research and Testing and Factors Influencing Their Intentions to Test
Potential Consumers' Attitudes Toward Psychiatric Genetic Research and Testing and Factors Influencing Their Intentions to Test
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DOI：
10.1089/gtmb.2008.0022
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发表时间：
2009-02-01
影响因子：
1.4
通讯作者：
Mors, Ole
中科院分区：
文献类型：
--
作者：
Laegsgaard, Mett Marri;Kristensen, Ann Suhl;Mors, Ole
精神病学基因研究使精神病学基因检测成为可能。基因检测的最佳和负责任的利用取决于对潜在消费者对检测的态度和期望的了解。本研究的目的是评估潜在消费者对精神病学遗传学的态度和期望，以及影响他们测试意愿的因素。为了评估人们对精神疾病基因检测的态度和意向，我们将一份问卷邮寄或亲自发给参加旨在确定易患精神疾病基因的不同基因研究的个人。共有397名被诊断为重度抑郁症、双相情感障碍、精神分裂症或焦虑症的人参与了这项调查。绝大多数样本都表达了他们自己和他们的孩子参加精神病基因测试的意愿。对产前检查的支持要弱得多。很大一部分人表示，不管治疗的可能性如何，他们都打算进行测试。测试的意愿与为人父母、对研究人员的信任、以及在知道风险基因存在时希望更好地准备好对抗这种疾病呈正相关。意愿与精神病学基因研究带来的太多困难选择的恐惧负相关，并担心无法应对精神病学基因测试的结果。这些结果表明，精神病学基因检测不仅仅被认为是一种更好的治疗方法。其他期望可能会激励测试，即使测试的临床有效性很差。
Psychiatric genetic research brings on the possibility of psychiatric genetic testing. The optimal and responsible utilization of genetic testing depends on knowledge of the potential consumers' attitudes and expectations regarding testing. The aim of this study was to assess potential consumers' attitudes and expectations toward psychiatric genetics and factors influencing their intentions to test. A questionnaire constructed to assess attitudes and intentions toward psychiatric genetic testing was mailed or given in person to individuals participating in different genetic studies aiming at identifying genes predisposing for mental illness. A total of 397 persons diagnosed with major depression, bipolar disorder, schizophrenia, or anxiety disorder participated in the survey. A large majority of the sample expressed an intention for themselves and their children to participate in psychiatric genetic testing. Support for prenatal testing was considerably less strong. A large minority expressed intention to test regardless of treatment possibilities. Intentions to test were positively associated with being a parent, trust in researchers, and expecting to feel better prepared for fighting the disorder when knowing of the presence of risk genes. Intentions were negatively associated with the fear of psychiatric genetic research bringing on too many difficult choices and fearing not to be able to cope with the results of a psychiatric genetic test. These results indicate that psychiatric genetic testing is not just perceived as a way to better treatment. Other expectations may motivate testing even though the clinical validity of the test is poor.