Breathhold multiecho fast spin-echo pulse sequence for accurate R2 measurement in the heart and liver.
Breathhold multiecho fast spin-echo pulse sequence for accurate R2 measurement in the heart and liver.
复制标题
DOI：
10.1002/mrm.22047
复制
发表时间：
2009-08
影响因子：
3.3
通讯作者：
Brittenham, Gary M.
中科院分区：
文献类型：
--
作者：
Kim, Daniel;Jensen, Jens H.;Wu, Ed X.;Sheth, Sujit S.;Brittenham, Gary M.
质子横向弛豫率（R2）的测量通常是用于定量表征具有各种临床应用的组织中的病理变化的有用手段。最广泛使用的R2测量方法是Carr-Purcell-Meiboom-Gill（CPMG）脉冲序列，但其相对较长的扫描时间需要呼吸门控用于胸部或身体MRI，使得这种方法在临床可接受的检查时间内进行全面评估不切实际。本研究的目的是开发一种屏气多回波快速自旋回波（FSE）序列，用于准确测量肝脏和心脏中的R2。进行了体模实验和受试者在体研究，以比较FSE数据与相应的均匀回波CPMG数据。对于合并数据，两个脉冲序列之间的R2测量值具有强相关性（Pearson相关系数= 0.99），并且具有极好的一致性（平均差[CPMG-FSE] = 0.10 s-1; 95%一致性限值为1.98和-1.78 s-1）。
Measurement of proton transverse relaxation rates (R2) is a generally useful means for quantitative characterization of pathological changes in tissue with a variety of clinical applications. The most widely used R2 measurement method is the Carr-Purcell-Meiboom-Gill (CPMG) pulse sequence but its relatively long scan time requires respiratory gating for chest or body MRI, rendering this approach impractical for comprehensive assessment within a clinically acceptable examination time. The purpose of our study was to develop a breath-hold multi-echo fast spin-echo (FSE) sequence for accurate measurement of R2 in the liver and heart. Phantom experiments and studies of subjects in vivo were performed to compare the FSE data with the corresponding even-echo CPMG data. For pooled data, the R2 measurements were strongly correlated (Pearson correlation coefficient = 0.99) and in excellent agreement (mean difference [CPMG-FSE] = 0.10 s−1; 95% limits of agreement were 1.98 and −1.78 s−1) between the two pulse sequences.
登录
查看更多内容
影响因子：
3.3
作者：
Huang, Teng-Yi;Liu, Yi-Jui;Poncelet, Brigitte P.
通讯作者：
Poncelet, Brigitte P.
影响因子：
19.7
作者：
KUCHARCZYK, W;BRANTZAWADZKI, M;NORMAN, D
通讯作者：
NORMAN, D
影响因子：
19.7
作者：
OHTOMO, K;ITAI, Y;IIO, M
通讯作者：
IIO, M
影响因子：
19.7
作者：
RYDBERG, JN;LOMAS, DJ;RIEDERER, SJ
通讯作者：
RIEDERER, SJ
影响因子：
3.3
作者：
CONSTABLE, RT;GORE, JC
通讯作者：
GORE, JC