Phase-shifting effects of a serotonin agonist in tau mutant hamsters.
Phase-shifting effects of a serotonin agonist in tau mutant hamsters.
复制标题
tau 突变仓鼠中血清素激动剂的相移效应。
DOI：
10.1016/0006-8993(96)00596-3
复制
发表时间：
1996
期刊：
影响因子：
2.9
通讯作者：
Turek,FW
中科院分区：
文献类型：
--
作者：
Colecchia,EF;Penev,PD;Zee,PC;Turek,FW
先前的研究表明，与野生型动物相比，tau突变仓鼠对非光刺激（如NPY和轮脉冲）的相位响应曲线（PRC）的提前区域的特征在于更早的时间和增加的幅度。因为，最近的证据表明，多巴胺能通路可能在啮齿动物昼夜节律起搏器的非光相重置中起重要作用，PRCs对5-羟色胺（5-HT）激动剂8-OH-DPAT（5 mg/kg i. p.），在保持在恒定黑暗中的野生型和tau突变仓鼠中产生。结果表明，tau蛋白突变与时间的变化，但不是幅度的提前区域的PRC 8-OH-DPAT，并建议，多巴胺能药物和其他非光或活动诱导的刺激可能有一些共同的机制重置啮齿动物昼夜节律起搏器的相位。
Previous studies indicate that the advance region of the tau mutant hamster's phase-response curve (PRC) to non-photic stimuli, such as NPY and wheel pulses, is characterized by earlier timing and increased amplitude in comparison with that of wild-type animals. Since, recent evidence suggests that serotonergic pathways may play an important role for the non-photic phase resetting of the rodent circadian pacemaker, PRCs to the serotonin (5-HT) agonist, 8-OH-DPAT (5 mg/kg i.p.), were generated in both wild-type and tau mutant hamsters kept in constant darkness. The results indicate that the tau mutation is associated with changes in the timing, but not the amplitude of the advance region of the PRC to 8-OH-DPAT and suggest that serotonergic agents and other non-photic or activity-inducing stimuli may share some common mechanisms for resetting the phase of the rodent circadian pacemaker.