Methylenetetrahydrofolate reductase 677 C->T polymorphism: A link between birth weight and insulin resistance in obese adolescents
Methylenetetrahydrofolate reductase 677 C->T polymorphism: A link between birth weight and insulin resistance in obese adolescents
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DOI：
10.3109/17477166.2010.486835
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发表时间：
2011-06-01
影响因子：
--
通讯作者：
De Courcy, Genevieve Potier
中科院分区：
文献类型：
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作者：
Frelut, Marie-Laure;Nicolas, Jean-Pierre;De Courcy, Genevieve Potier
这项研究的目的是确定心血管风险和亚甲基四氢叶酸还原酶677 C->T多态性（MTHFR），一种参与叶酸代谢和表观遗传学的酶，与病态肥胖的非糖尿病青少年有关。研究对象为14.4 +/- 1.5岁的青少年（BMI = 39.1 +/- 6.4 kg/m2），他们在进入减肥计划前接受了调查。从出生时（n = 107）、1岁（n = 102）、2岁（n = 106）、4岁（n = 91）和8岁（n = 73）的个人健康记录中获得生长信息。TT组的出生体重较低（2.95 +/- 0.48 kg，p = 0.004）（3.34 +/- 0.43 kg）和CT（3.38 +/- 0.50 kg）受试者，以及出生身长（CC：0.50 +/- 0.02 m，CT：0.50 +/- 0.02 m，TT：0.47 +/- 0.03 m，p = 0.01）。这些差异一直持续到1岁。中位和平均空腹血糖相似。TT（中位数：26.4 UI/mL）受试者的胰岛素水平高于CC（中位数：15.0 UI/mL）或CT（中位数：16.0 UI/mL）（p = 0.017）受试者，HOMA IR（p = 0.04）受试者也是如此。3种基因型的男孩和女孩的身体成分、血压、血脂、同型半胱氨酸和瘦素浓度相似。因此，常见的677 C->T突变似乎代表了肥胖青少年早期生长改变和后期胰岛素抵抗程度增强之间的联系。
The goal of this study is to determine whether cardiovascular risk and the methylenetetrahydrofolate reductase 677 C->T polymorphism (MTHFR), an enzyme involved in folate metabolism and in epigenetics, are linked in morbidly obese nondiabetic adolescents.One-hundred and thirteen obese (BMI = 39.1 +/- 6.4 kg/m(2)) adolescents aged 14.4 +/- 1.5 years were investigated before entering a weight reduction program. Information on growth obtained from individual health records was available at birth (n = 107), 1 (n = 102), 2 (n = 106), 4 (n = 91) and 8 (n = 73) years of age.Fifty-nine subjects were heterozygote (CT, 52.2%) and 8 were homozygote for the mutation (TT, 7.0%). Birth weights were lower in TT (2.95 +/- 0.48 kg, p = 0.004) than in CC (3.34 +/- 0.43 kg) and CT (3.38 +/- 0.50 kg) subjects, as well as birth lengths (CC: 0.50 +/- 0.02 m, CT : 0.50 +/- 0.02 m, TT: 0.47 +/- 0.03 m, p = 0.01). These differences persisted until 1 year of age. Median and mean fasting glycaemia were similar. Insulin levels were higher in TT (median: 26.4 UI/mL) than in CC (median: 15.0 UI/mL) or CT (median: 16.0 UI/mL) (p = 0.017) subjects, as well as HOMA IR (p = 0.04). Body composition, blood pressure, plasma lipids, homocysteine and leptin concentrations were similar among the three genotypes in both boys and girls.The common 677 C->T mutation seems therefore to represent a link between altered early growth and enhanced degree of insulin resistance that occurs later in obese adolescents.