Diurnal rhythm of cerebrospinal fluid and plasma leptin levels related to feeding in non-lactating and lactating rats
Diurnal rhythm of cerebrospinal fluid and plasma leptin levels related to feeding in non-lactating and lactating rats
复制标题
DOI：
10.1677/joe.0.1800283
复制
发表时间：
2004-02-01
影响因子：
4
通讯作者：
Terashima, Y
中科院分区：
文献类型：
--
作者：
Asakuma, S;Hiraku, O;Terashima, Y
瘦素抑制食物摄入并增加下丘脑的能量消耗。大鼠在昼夜循环的黑暗阶段消耗其每日食物摄入量的大部分。哺乳期大鼠的食物摄入量增加，但在这种生理条件下，瘦素参与调节食物摄入量还不清楚。本实验旨在研究血浆和脑脊液中瘦素浓度与哺乳期和非哺乳期大鼠摄食行为之间的昼夜节律关系。雌性大鼠保持受控的光照时间表（0600 ~ 1800 h光照），哺乳期大鼠的摄食量是非哺乳期大鼠的2 ~ 3倍。在两组中，黑暗期的食物摄入量是对照组的三倍（P
Leptin suppresses food intake and increases energy expenditure in the hypothalamus. Rats consume most of their daily food intake during the dark phase of the diurnal cycle. Lactating rats have increased food intake, but the involvement of leptin in the regulation of food intake in this physiological condition is not well understood. The present experiment was carried out to determine the circadian pattern of leptin concentrations in plasma and cerebrospinal fluid (CSF) in relation to the feeding behavior of non-lactating and lactating rats.Female rats were maintained on a controlled lighting schedule (lights on between 0600 and 1800 h) and the food intake of lactating rats was two- or threefold higher than that of non-lactating rats. In both groups, food intake was three times greater in the dark phase (P