UK quantitative WB-DWI technical workgroup: consensus meeting recommendations on optimisation, quality control, processing and analysis of quantitative whole-body diffusion-weighted imaging for cancer.
UK quantitative WB-DWI technical workgroup: consensus meeting recommendations on optimisation, quality control, processing and analysis of quantitative whole-body diffusion-weighted imaging for cancer.
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DOI：
10.1259/bjr.20170577
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发表时间：
2018-01
期刊：
影响因子：
--
通讯作者：
Punwani S
中科院分区：
文献类型：
--
作者：
Barnes A;Alonzi R;Blackledge M;Charles-Edwards G;Collins DJ;Cook G;Coutts G;Goh V;Graves M;Kelly C;Koh DM;McCallum H;Miquel ME;O'Connor J;Padhani A;Pearson R;Priest A;Rockall A;Stirling J;Taylor S;Tunariu N;van der Meulen J;Walls D;Winfield J;Punwani S
全身扩散加权MRI（WB-DWI）在肿瘤学中的应用在研究和常规临床领域都在迅速增加。然而，WB-DWI作为定量成像生物标志物（QIB）的采用速度明显较慢。迄今为止，与准确性和再现性相关的挑战，良好QIB的基本标准，限制了广泛的临床翻译。鉴于此，英国于2016年成立了一个研究小组，以提供技术共识指南（以最大限度地提高WB-MRI QIB的准确性和再现性），并加速定量WB-DWI应用于肿瘤学的临床转化。来自英国各地癌症中心的专家小组，具有定量成像和/或使用WB-MRI和DWI的亚专业知识。一个正式的共识方法被用来获得关于最佳实践的共识协议。询问了有关扫描仪硬件和软件、序列优化、采集方案、报告和持续质量控制计划的适当性或其他问题，以监测精密度和准确度以及质量控制协议。共识小组能够就73%（255/351）的项目达成共识，并根据共识领域提出建议，以最大限度地提高在1.5T下进行的定量WB-DWI研究的准确性和可重复性。专家组无法就与在3 T下进行的定量WB-DWI相关的大多数项目达成共识。本英国定量WB-DWI技术工作组共识为最大限度地提高肿瘤定量WB-DWI的准确性和可重复性提供了指导。研究人员和临床医生可以使用共识指南来协调WB-DWI方案，这将加速WB-DWI衍生QIB的临床转化。
Application of whole body diffusion-weighted MRI (WB-DWI) for oncology are rapidly increasing within both research and routine clinical domains. However, WB-DWI as a quantitative imaging biomarker (QIB) has significantly slower adoption. To date, challenges relating to accuracy and reproducibility, essential criteria for a good QIB, have limited widespread clinical translation. In recognition, a UK workgroup was established in 2016 to provide technical consensus guidelines (to maximise accuracy and reproducibility of WB-MRI QIBs) and accelerate the clinical translation of quantitative WB-DWI applications for oncology. A panel of experts convened from cancer centres around the UK with subspecialty expertise in quantitative imaging and/or the use of WB-MRI with DWI. A formal consensus method was used to obtain consensus agreement regarding best practice. Questions were asked about the appropriateness or otherwise on scanner hardware and software, sequence optimisation, acquisition protocols, reporting, and ongoing quality control programs to monitor precision and accuracy and agreement on quality control. The consensus panel was able to reach consensus on 73% (255/351) items and based on consensus areas made recommendations to maximise accuracy and reproducibly of quantitative WB-DWI studies performed at 1.5T. The panel were unable to reach consensus on the majority of items related to quantitative WB-DWI performed at 3T. This UK Quantitative WB-DWI Technical Workgroup consensus provides guidance on maximising accuracy and reproducibly of quantitative WB-DWI for oncology. The consensus guidance can be used by researchers and clinicians to harmonise WB-DWI protocols which will accelerate clinical translation of WB-DWI-derived QIBs.
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DOI：
10.1016/j.nicl.2014.08.008
发表时间：
2014
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Shinohara RT;Sweeney EM;Goldsmith J;Shiee N;Mateen FJ;Calabresi PA;Jarso S;Pham DL;Reich DS;Crainiceanu CM;Australian Imaging Biomarkers Lifestyle Flagship Study of Ageing;Alzheimer's Disease Neuroimaging Initiative
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DOI：
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发表时间：
2013-02-01
影响因子：
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作者：
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影响因子：
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19.7
作者：
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