Specification of jaw subdivisions by Dix genes
Specification of jaw subdivisions by Dix genes
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DOI：
10.1126/science.1075703
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发表时间：
2002-10-11
期刊：
影响因子：
56.9
通讯作者：
Rubenstein, JLR
中科院分区：
文献类型：
--
作者：
Depew, MJ;Lufkin, T;Rubenstein, JLR
脊椎动物的成功部分归功于颌骨的获得和改造。颌骨主要来源于颧弓，这是一种表现出近端和远端极性的胚胎结构。为了研究确定拱门内骨骼元素的特性的机制，我们研究了缺乏Dlx5和Dlx6表达的小鼠，Dlx5和Dlx6是连接的同源框基因，在拱门内表达在远端，而不是近端。Dlx5/6(-/-)突变体表现出从下颌骨到上颌骨的同源转化。我们认为，DLX在弓部的嵌套表达形成了它们的近端轴线。颌骨的进化获得和随后的精化可能依赖于DLX表达的修饰。
The success of vertebrates was due in part to the acquisition and modi cation of jaws. Jaws are principally derived from the branchial arches, embryonic structures that exhibit proximodistal polarity. To investigate the mechanisms that specify the identity of skeletal elements within the arches, we examined mice lacking expression of Dlx5 and Dlx6, linked homeobox genes expressed distally but not proximally within the arches. Dlx5/6(-/-) mutants exhibit homeotic transformation of lower jaws to upper jaws. We suggest that nested Dlx expression in the arches patterns their proximodistal axes. Evolutionary acquisition and subsequent refinement of jaws may have been dependent on modi cation of Dlx expression.