C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus
C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus
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DOI：
10.1001/jama.286.3.327
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发表时间：
2001-07-18
影响因子：
120.7
通讯作者：
Ridker, PM
中科院分区：
文献类型：
--
作者：
Pradhan, AD;Manson, JE;Ridker, PM
背景炎症被认为在2型糖尿病（DM）的发生发展中起作用;目的探讨炎症标志物白细胞介素6（IL-6）和C反应蛋白（CRP）水平升高是否与健康中年女性2型糖尿病的发生有关。巢式病例对照研究。背景妇女健康研究，一项始于1992年的正在进行的美国主要预防、随机临床试验。参与者来自一个全国性队列，包括27628名基线时未诊断为DM、心血管疾病和癌症的妇女，188例在4年随访期内确诊为DM的妇女被定义为病例，并与362例无疾病对照组的年龄和空腹状态相匹配。主要结果测量根据基线IL-6和CRP水平确诊为临床诊断的2型DM的发病率。结果基线IL-6水平（P < 0.05），
Context Inflammation is hypothesized to play a role in development of type 2 diabetes mellitus (DM); however, clinical data addressing this issue are limited.Objective To determine whether elevated levels of the inflammatory markers interleukin 6 (IL-6) and C-reactive protein (CRP) are associated with development of type 2 DM in healthy middle-aged women.Design Prospective, nested case-control study.Setting The Women's Health Study, an ongoing US primary prevent ion, randomized clinical trial initiated in 1992.Participants From a nationwide cohort of 27 628 women free of diagnosed DM, cardiovascular disease, and cancer at baseline, 188 women who developed diagnosed DM over a 4-year follow-up period were defined as cases and matched by age and fasting status with 362 disease free controls.Main Outcome Measures Incidence of confirmed clinically diagnosed type 2 DM by baseline levels of IL-6 and CRP.Results Baseline levels of IL-6 (P