Initiating the development of multisensory integration by manipulating sensory experience.
Initiating the development of multisensory integration by manipulating sensory experience.
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DOI：
10.1523/jneurosci.5575-09.2010
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发表时间：
2010-04-07
期刊：
影响因子：
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通讯作者：
Stein BE
中科院分区：
文献类型：
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作者：
Yu L;Rowland BA;Stein BE
上级丘（SC）神经元的多感觉整合能力逐渐出现在出生后的早期生活作为一个结果的经验与跨通道的刺激。如果没有这样的经验，神经元会对多种感觉方式做出反应，但无法整合它们的输入。本研究表明，神经元保持敏感性，跨模态的经验以及过去的正常发育期获得多感觉整合能力。令人惊讶的是，在生命后期的经验被发现可以迅速启动多感觉整合的发展，甚至比基于其正常发育时间过程的预期更快。此外，所需的经验是由麻醉的大脑获得的，并且没有任何与学习有关的刺激-反应偶然性。关键的经验因素是重复暴露于相关刺激，这需要多感觉神经元的多个感受野包含交叉模态暴露部位。在这方面，简单地暴露于跨模态刺激的各个组成部分是无效的。此外，一旦神经元在暴露部位获得了多感觉整合能力，它就会将这种体验推广到其他部位，尽管效果较低。这些观察结果表明，多感觉整合正常出现的时间延长是由于神经回路中的发育因素，以及纳入跨模态事件统计所需的因素;神经元根据经验的具体情况学习多感觉原理，然后可以将其应用于其他刺激条件;这种多感官信息的整合并不依赖于警觉的大脑。
The multisensory integration capabilities of superior colliculus (SC) neurons emerge gradually during early postnatal life as a consequence of experience with cross-modal stimuli. Without such experience neurons become responsive to multiple sensory modalities but are unable to integrate their inputs. The present study demonstrates that neurons retain sensitivity to cross-modal experience well past the normal developmental period for acquiring multisensory integration capabilities. Experience surprisingly late in life was found to rapidly initiate the development of multisensory integration, even more rapidly than expected based on its normal developmental time course. Furthermore, the requisite experience was acquired by the anesthetized brain and in the absence of any of the stimulus-response contingencies generally associated with learning. The key experiential factor was repeated exposure to the relevant stimuli, and this required that the multiple receptive fields of a multisensory neuron encompassed the cross-modal exposure site. Simple exposure to the individual components of a cross-modal stimulus was ineffective in this regard. Furthermore, once a neuron acquired multisensory integration capabilities at the exposure site, it generalized this experience to other locations, albeit with lowered effectiveness. These observations suggest that the prolonged period during which multisensory integration normally appears is due to developmental factors in neural circuitry in addition to those required for incorporating the statistics of cross-modal events; that neurons learn a multisensory principle based on the specifics of experience and can then apply it to other stimulus conditions; and that the incorporation of this multisensory information does not depend on an alert brain.